Active transport of cytoophidia in Schizosaccharomyces pombe

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Hui LiJi-Long Liu

Abstract

The metabolic enzyme cytidine triphosphate synthase has recently been found to form micrometer-sized filamentous structures termed cytoophidia, which are evolutionarily conserved across prokaryotes and eukaryotes. The cytoophidium represents a novel type of membraneless organelle and behaves dynamically inside the cell. The question of how cytoophidia transport is mediated, however, remains unanswered. For the first time, we detected in this study the active transport of cytoophidia, taking advantage of the fission yeast Schizosaccharomyces pombe as an excellent model for studying membraneless organelles. We demonstrated that actin filaments, not microtubules, are responsible for this transport. Furthermore, we determined that Myo52, a type of myosin V, is required for the active transport of cytoophidia. These results reveal the major players critical to the dynamics of cytoophidia and extend our understanding of intracellular transport of membraneless organelles.-Li, H., Ye, F., Ren, J.-Y., Wang, P.-Y., Du, L.-L., Liu, J.-L. Active transport of cytoophidia in Schizosaccharomyces pombe.

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Citations

Apr 16, 2020·Environmental Microbiology·Antoine Danchin, Philippe Marlière
Aug 23, 2019·The Journal of Biological Chemistry·Christos AndreadisJi-Long Liu
Oct 31, 2020·Genome Biology and Evolution·Zhihua OuAntoine Danchin
Feb 10, 2021·G3 : Genes - Genomes - Genetics·Shanshan ZhangJi-Long Liu
Apr 23, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Bo ZhangJi-Long Liu
Jun 9, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Shuang ZhouJi-Long Liu
Mar 20, 2021·Experimental Cell Research·Qiao-Qi WangJi-Long Liu
Apr 5, 2021·Experimental Cell Research·Han-Chao FengJi-Long Liu

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Methods Mentioned

BETA
confocal
fluorescence microscopy
confocal microscopy

Software Mentioned

ImageJ Tracker

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