PMID: 5914252Sep 1, 1966

Active transport of sodium and potassium in mammalian skeletal muscle and its modification by nerve and by cholinergic and adrenergic agents

The Journal of Physiology
M DockryA Tangney

Abstract

1. Active transport of Na(+) and K(+) by Na-rich extensor digitorum and soleus muscles of rat was found to be increased considerably when muscles were innervated during enrichment with Na(+) in K-free modified Krebs solution containing 160 mM-Na at 2 degrees C and recovery in a similar fluid with 10 mM-K and 137 mM-Na at 37 degrees C, bubbled with oxygen.2. Addition of acetylcholine (2.0 mug/ml.) to recovery fluid containing denervated extensors increased active transport, whereas addition of eserine (50 mug/ml.), decamethonium (0.1 mug/ml.) and to a lesser extent tubocurarine (0.26 mug/ml.) inhibited active transport. Blocking of nerve conduction in innervated extensor inhibited K(+) uptake more than Na(+) excretion.3. The membrane potential of Na-rich extensor muscles measured soon after re-immersion in recovery fluid was higher in denervated than in innervated muscles. In the latter it was close to the K-equilibrium potential (E(K)). It is suggested that denervation here makes the Na-pump electrogenic by decreasing K(+) uptake either by decreased permeability or by inactivating a K-pump. Evidence is presented that the latter is more likely.4. Addition of isoprenaline to Na-rich soleus muscles in recovery fluid increased acti...Continue Reading

Citations

Jan 1, 1978·Progress in Neurobiology·K Kuba, K Koketsu
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·H ZemkováF Vyskocil
Nov 1, 1977·Journal of the Neurological Sciences·G M BrayA J Aguayo
Dec 7, 1979·Brain Research·N Akaike
Jun 1, 1984·Journal of Cellular Physiology·H H Vandenburgh, C M Lent
Aug 1, 1983·Pflügers Archiv : European journal of physiology·G PflieglerT Kovács
Mar 1, 1988·Pflügers Archiv : European journal of physiology·K Ballanyi, P Grafe
Jan 1, 1971·Pflügers Archiv : European journal of physiology·E X AlbuquerqueF C Kauffman
Mar 16, 1979·Pflügers Archiv : European journal of physiology·N Akaike
Sep 1, 1985·Pflügers Archiv : European journal of physiology·K KaibaraK Koketsu
Aug 25, 1972·Annals of the New York Academy of Sciences·S Ochs
Jun 1, 1987·Journal of Autonomic Pharmacology·M S Elfellah, J L Reid
May 12, 2016·American Journal of Physiology. Endocrinology and Metabolism·Sergej Pirkmajer, Alexander V Chibalin
Sep 25, 2003·Physiological Reviews·T Clausen
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·T Clausen
Feb 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E G Klaver-KrolM J Zwarts

Related Concepts

Acetylcholine Sulfate (1: 1)
Decamethonium Compounds
Novodrin
Muscle Denervation Procedure
Muscle
Nerve Conduction Function
Eserine
Potassium
Sodium
Tubocurarine Chloride

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.