Active tuberculosis case finding and detection of drug resistance among HIV-infected patients: A cross-sectional study in a TB endemic area, Gondar, Northwest Ethiopia

International Journal of Mycobacteriology
Martha AlemayehuAbraham Aseffa

Abstract

Tuberculosis (TB) patients co-infected with human immunodeficiency virus (HIV) often lack the classic symptoms of pulmonary tuberculosis, making the diagnosis difficult. Current practices in resource-limited settings often indicate that these co-infected patients are diagnosed when they clinically manifest disease symptoms, resulting in a delayed diagnosis and despite continued transmission. The aim of this study is to determine the prevalence of undiagnosed pulmonary tuberculosis cases through active case finding and including multidrug-resistant TB (MDR-TB) among HIV-infected patients. A total of 250 HIV-infected patients, aged 18years and above were evaluated in a cross-sectional design between February 2012 and November 2012. Socio-demographic and clinical data were collected using a structured questionnaire. Sputum samples were collected from all participants for acid fast bacilli (AFB) direct smear microscopy and Mycobacteria culture. A PCR-based RD9 deletion and genus typing, as well as first-line anti-TB drug susceptibility testing, was performed for all culture-positive isolates. Following active TB case finding, a total of 15/250 (6%) cases were diagnosed as TB cases, of whom 9/250 (3.6%) were detected by both smear m...Continue Reading

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Citations

Jul 19, 2015·Journal of Translational Medicine·Andargachew MuluSisay Yifru
Jun 19, 2019·Open Forum Infectious Diseases·Russell R KempkerNestani Tukvadze
Dec 20, 2018·BMC Infectious Diseases·Mebrahtu TeweldemedhinSolomon Weldegebreal Asgedom
Jun 9, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Mengistu AbaynehAbyot Asres
Dec 7, 2021·Journal of Pharmaceutical Health Care and Sciences·Temesgen MulugetaBehailu Terefe

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