PMID: 2491624Jan 1, 1989Paper

Actively-induced experimental allergic orchitis (EAO) in Lewis/NCR rats: sequential histo- and immunopathologic analysis

Autoimmunity
Z Z ZhouC Teuscher

Abstract

Active experimental allergic orchitis (EAO) was induced in Lewis/NCr rats by immunization with homologous rat testicular homogenate. Groups of animals were studied sequentially at five day intervals for histopathologic signs of disease. Inflammatory lesions were first observed in the ductus efferentes as early as 5 days following immunization. Immunohistochemical analysis of the testes, rete testis, ductus efferentes and caput, corpus and cauda epididymis of immunized rats on day five revealed that only the ductus efferentes exhibited a significant increase in the number of interstitial cells expressing Ia antigens (MRC OX-6) as well as CD4 (W3/25) positive helper/inducer T lymphocytes, CD8 (MRC OX-8) positive cytotoxic T lymphocytes and/or natural killer cells and macrophages (MRC OX-42). Increased staining for Ia antigens was also associated with both the vascular and ductal epithelial cells whereas cells within the lumen of the ducts were consistently negative for Ia antigen expression. In contrast, there was no detectable increase in the level of expression of rat MHC class I antigens (MRC OX-18) by any of the cells of the ductus efferentes. Similarly, there was no increase in the number of MAR 18.5 and/or MRC OX-12 positiv...Continue Reading

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Citations

Jan 1, 1995·Microscopy Research and Technique·C J FlickingerJ C Herr
Feb 1, 1995·Journal of Reproductive Immunology·P Pöllänen, T G Cooper
May 1, 1994·Journal of Reproductive Immunology·P Pöllänen, T G Cooper
Jan 1, 1991·American Journal of Reproductive Immunology : AJRI·G F Doncel, L Lustig
Jan 1, 1993·The Anatomical Record·C J FlickingerS S Howards
Aug 11, 2005·The Journal of Pathology·Monika FijakAndreas Meinhardt
Apr 7, 2010·Molecular and Cellular Endocrinology·Andreas Meinhardt, Mark P Hedger
Aug 1, 1996·Journal of Reproductive Immunology·T SaariP Pöllänen
Apr 3, 2014·Toxicologic Pathology·Guenther HoffmannLuke Muhumuza
Sep 16, 2006·Immunological Reviews·Monika Fijak, Andreas Meinhardt

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