Activin A and Late Postpartum Cardiac Dysfunction Among Women With Hypertensive Disorders of Pregnancy

Hypertension
Sajid ShahulSarosh Rana

Abstract

Women with hypertensive disorders of pregnancy have an increased risk of subsequent heart failure and cardiovascular disease when compared with women with normotensive pregnancies. Although the mechanisms underlying these findings are unclear, elevated levels of the biomarker activin A are associated with myocardial dysfunction and may have predictive value. We hypothesized that elevated levels of antepartum activin A levels would correlate with postpartum cardiac dysfunction in women with hypertensive disorders of pregnancy. We prospectively studied 85 women to determine whether increased antepartum activin A levels were associated with cardiac dysfunction at 1 year postpartum as measured by global longitudinal strain. Thirty-two patients were diagnosed with preeclampsia, 28 were diagnosed with gestational or chronic hypertension, and the remainder were nonhypertensive controls. Activin A levels were measured with ELISA both in the third antepartum trimester and at 1 year postpartum. Comprehensive echocardiograms including measurement of global longitudinal strain were also performed at enrollment and at 1 year postpartum. Antepartum activin A levels correlated with worsening antepartum global longitudinal strain (r=0.70; P=0....Continue Reading

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Citations

Mar 29, 2019·Circulation Research·Sarosh RanaS Ananth Karumanchi
Jun 4, 2019·Hypertension·UNKNOWN Editors
Jun 7, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi Masutani
Jun 5, 2020·Journal of the American Heart Association·Heba NaseemSajid Shahul
Nov 23, 2019·Current Treatment Options in Cardiovascular Medicine·Anna C O'KellySammy Zakaria
Aug 29, 2020·Obstetrical & Gynecological Survey·Suzanne MoorsJudith O E H van Laar
Nov 9, 2019·Journal of the American Heart Association·Maya ReddyKirsten Palmer
Mar 8, 2019·Science Translational Medicine·Jason D RohAnthony Rosenzweig
Sep 28, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·V GiorgioneB Thilaganathan
Dec 22, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lisa LevineBonnie Ky
Feb 24, 2021·Journal of the American Heart Association·Victoria A deMartellySajid Shahul
Oct 24, 2020·American Journal of Obstetrics and Gynecology·Sarosh RanaS Ananth Karumanchi
Aug 14, 2021·Cardiovascular Endocrinology & Metabolism·Sonia A El-SaiediAntoine F AbdelMassih

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