Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct

Developmental Biology
Akito MaeshimaSanjay K Nigam

Abstract

Development of metanephric kidney begins with ureteric bud outgrowth from the Wolffian duct (WD). GDNF is believed to be a crucial positive signal in the budding process, but the negative regulation of this process remains unclear. Here, we examined the role of activin A, a member of TGF-beta family, in bud formation using an in vitro WD culture system. When cultured with the surrounding mesonephros, WDs formed many ectopic buds in response to GDNF. While the activin signaling pathway is normally active along the non-budding WD (as measured by expression of activin A and phospho-Smad2/3), activin A was absent and phospho-Smad2/3 was undetectable in the ectopic buds induced by GDNF. To examine the role of activin A in bud formation, we attempted to inactivate activin action. Interestingly, the addition of neutralizing anti-activin A antibody potentiated GDNF action. To further clarify the role of activin A, we also tested the effect of activin blockade on the WD cultured in the absence of mesonephros. WDs without mesonephros did not form ectopic buds even in the presence of GDNF. In contrast, blockade of activin action with a variety of agents acting through different mechanisms (natural antagonist, neutralizing antibodies, siRN...Continue Reading

References

Feb 16, 1990·Science·T NakamuraH Sugino
Apr 1, 1989·Molecular Endocrinology·S ShimasakiN Ling
Jan 1, 1987·Differentiation; Research in Biological Diversity·L Saxén, E Lehtonen
Mar 23, 1995·Nature·M M MatzukA Bradley
Nov 1, 1996·Medical and Pediatric Oncology·G R Dressler
Apr 1, 1997·Mechanisms of Development·A FainsodM Blum
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·J QiaoS K Nigam
Feb 19, 2000·Biochemical and Biophysical Research Communications·A MaeshimaI Kojima
Apr 5, 2000·The Journal of Clinical Investigation·Y MiyazakiI Ichikawa
Jul 14, 2001·Molecular and Cellular Endocrinology·H ChangM M Matzuk
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Akito MaeshimaItaru Kojima
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Dec 14, 2001·Biochemical and Biophysical Research Communications·F OtsukaS Shimasaki
Jan 30, 2002·Experimental Biology and Medicine·Ye-Guang ChenShao-Yao Ying
Feb 16, 2002·Developmental Biology·Ming-Jer TangGregory R Dressler
Feb 19, 2002·Kidney International·Iekuni IchikawaYoichi Miyazaki
Sep 27, 2002·Experimental Biology and Medicine·Corrine WeltAlan Schneyer
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Akito MaeshimaItaru Kojima
May 6, 2003·Developmental Biology·Aurora F Esquela, Se-Jin Lee
May 23, 2003·Journal of the American Society of Nephrology : JASN·Akito MaeshimaYoshihisa Nojima
Jan 30, 2004·Cytokine & Growth Factor Reviews·Mark de Caestecker
Mar 17, 2004·Development·Mita M ShahSanjay K Nigam
Mar 30, 2004·Nature Cell Biology·Ingrid RemyStephen W Michnick
Apr 6, 2004·Journal of Anatomy·Lydia Michael, Jamie A Davies
May 8, 2004·Developmental Cell·Uta GrieshammerGail R Martin
May 8, 2004·Trends in Biochemical Sciences·Peter ten Dijke, Caroline S Hill
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yukiko AbeKatsumasa Maeda
Sep 24, 2004·Current Opinion in Genetics & Development·Jing YuM Todd Valerius
Dec 29, 2004·Developmental Cell·Reena ShakyaFrank Costantini
Feb 5, 2005·Developmental Cell·M Albert BassonJonathan D Licht

❮ Previous
Next ❯

Citations

Dec 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·E RosinesS K Nigam
Jun 5, 2014·BioMed Research International·Akito MaeshimaYoshihisa Nojima
Oct 30, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ihor V Yosypiv
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Zubaida SaifudeenSamir S El-Dahr
Oct 13, 2009·Journal of the American Society of Nephrology : JASN·Zhibo GaiYasuteru Muragaki
Jun 4, 2011·Journal of Signal Transduction·Renfang SongIhor V Yosypiv
Sep 11, 2007·Endocrine Journal·Akito MaeshimaYoshihisa Nojima
Jun 27, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rafael S LindosoMarcelo Einicker-Lamas
Jul 21, 2009·Seminars in Nephrology·Kimberly J Reidy, Norman D Rosenblum
Sep 4, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Frank Costantini
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Peter V HauserNorimoto Yanagawa
Mar 19, 2015·Molecular Reproduction and Development·Vidya K Nagalakshmi, Jing Yu
Jan 12, 2010·Developmental Biology·Mita M ShahSanjay K Nigam
Mar 25, 2016·International Journal of Molecular Sciences·Ze-Yang DingXiao-Ping Chen
Aug 19, 2006·Differentiation; Research in Biological Diversity·Frank Costantini
Mar 13, 2009·Organogenesis·Wen-Chin LeeJamie Davies
Dec 13, 2018·Physiological Reviews·Enrrico BloiseFernando M Reis
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·Julio C MonteSanjay K Nigam
Nov 6, 2012·Journal of the American Society of Nephrology : JASN·Adrian S Woolf, Jamie A Davies
Nov 16, 2007·Journal of the American Society of Nephrology : JASN·Akito MaeshimaSanjay K Nigam
Dec 19, 2007·Clinical and Experimental Nephrology·Akito Maeshima
Nov 25, 2016·American Journal of Physiology. Renal Physiology·Anastasie Tshilela KadiomboYoshihisa Nojima
Nov 19, 2008·Critical Reviews in Biochemistry and Molecular Biology·Victoria FrostAndrew Chantry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Eran RosinesSanjay K Nigam
Journal of the American Society of Nephrology : JASN
Akito MaeshimaSanjay K Nigam
BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Frank Costantini, Reena Shakya
© 2022 Meta ULC. All rights reserved