Activin A reduces luteinisation of human luteinised granulosa cells and has opposing effects to human chorionic gonadotropin in vitro.

The Journal of Endocrinology
Michelle MyersW Colin Duncan

Abstract

The transition of the dominant follicle into the corpus luteum is of fundamental reproductive importance. Luteinisation involves disparate changes in the gene expression of follicular granulosa cells that differentiate into the granulosa-lutein cells of the corpus luteum after the gonadotrophin surge. We have shown that activin and human chorionic gonadotropin (hCG) have opposing effects during luteolysis. Therefore, we hypothesised that activin A was an inhibitor of luteinisation that was blocked during the pre-ovulatory gonadotrophin surge. Ovarian tissue and cells were collected from women with regular cycles having hysterectomy and women undergoing oocyte retrieval for assisted conception. Genes that changes during luteinisation were investigated in primary cultures of luteinised granulosa cells exposed to activin A and hCG in vitro. hCG promotes a luteinised granulosa cell phenotype, while activin A promotes a more follicular phenotype in luteinised cells by upregulating granulosa cells markers such as FSHR, HSD11B2 and downregulating LHCGR. In addition, activin A blocked hCG upregulation of STAR, HSD3B1 and HSD11B1 and downregulation of oestrogen receptor alpha. Activin A antagonised hCG effects in a dose-dependent manner...Continue Reading

Citations

Mar 4, 2010·Journal of Assisted Reproduction and Genetics·Chi Christina DingEvelyn E Telfer
Mar 11, 2009·The Journal of Endocrinology·Yin Xia, Alan L Schneyer
Mar 1, 2013·Biology of Reproduction·Michelle MyersStephanie A Pangas
Jan 7, 2016·The Journal of Endocrinology·Anne R O'ConnellJennifer L Juengel
Jul 19, 2011·Molecular and Cellular Endocrinology·Stephanie A Pangas
Jun 15, 2011·Molecular and Cellular Endocrinology·Phil G KnightClaire Glister
Nov 1, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Pang-Pin LiuPeter C K Leung
Apr 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Bushra T MohammedF Xavier Donadeu
May 11, 2013·Molecular Endocrinology·Agne Velthut-MeikasAndres Salumets
Aug 14, 2020·Journal of Ovarian Research·Brandon A WyseClifford L Librach
Mar 24, 2017·Molecular Human Reproduction·Junko Nio-KobayashiW Colin Duncan

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