Activin-A secretion is increased in the eutopic endometrium from women with endometriosis

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Luk RombautsDavid L Healy

Abstract

Activin is a well-characterised growth and differentiation factor and an important inflammatory mediator. Activin is secreted by normal endometrial glands and stroma and is expressed by endometrial leucocytes. It is also known that the eutopic endometrium from women with endometriosis is functionally different to that from women without endometriosis. In this study, we hypothesise that the endometrial secretion of activin is altered in women with endometriosis. To determine whether the expression of inhibin/activin subunits and the secretion of activin-A is different in eutopic endometrium from women with and without endometriosis. Endometrial biopsies were obtained from premenopausal, regularly menstruating women with and without endometriosis. Staining intensity for the different inhibin/activin subunits was compared in endometrial and endometriotic biopsies. Activin-A secretion was studied using endometrial explants and endometrial glandular and stromal monolayer cell cultures. The alpha- and betaA-subunits of inhibin/activin were more abundant in eutopic glandular cells from patients with minimal to mild endometriosis compared to women without endometriosis. In patients with endometriosis, the betaB-subunit was more abundan...Continue Reading

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Citations

Jun 25, 2009·Human Reproduction·P FlorioF Petraglia
Mar 25, 2008·Molecular Human Reproduction·M C FerreiraF M Reis
Oct 24, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Larissa M CoutinhoFernando M Reis
May 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cynthia Dela Cruz, Fernando M Reis
Jan 7, 2016·The Journal of Endocrinology·Anne R O'ConnellJennifer L Juengel
Nov 23, 2012·Reproductive Sciences·Ikumi AkiyamaShiro Kozuma
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Oct 22, 2011·Expert Review of Clinical Immunology·Natalie J HannanLois A Salamonsen
Aug 25, 2009·Reproduction, Fertility, and Development·Lois A SalamonsenEvdokia Dimitriadis
Dec 17, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Zhen HouJiayin Liu
Mar 14, 2007·Molecular Human Reproduction·J Julie KimA T Fazleabas
Jul 24, 2021·Evolutionary Applications·Natalie L Dinsdale, Bernard J Crespi
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology

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