Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizures

The Journal of Comparative Neurology
Jane A FosterMiles Herkenham

Abstract

The progressive development of seizures in rats by amygdala kindling, which models temporal lobe epilepsy, allows the study of molecular regulators of enduring synaptic changes. Neurotrophins play important roles in synaptic plasticity and neuroprotection. Activin, a member of the transforming growth factor-beta superfamily of growth and differentiation factors, has recently been added to the list of candidate synaptic regulators. We mapped the induction of activin betaA mRNA in amygdala and cortex at several stages of seizure development. Strong induction, measured 2 hours after the first stage 2 (partial) seizure, appeared in neurons of the ipsilateral amygdala (confined to the lateral, basal, and posterior cortical nuclei) and insular, piriform, orbital, and infralimbic cortices. Activin betaA mRNA induction, after the first stage 5 (generalized) seizure, had spread to the contralateral amygdala (same nuclear distribution) and cortex, and the induced labeling covered much of the convexity of neocortex as well as piriform, perirhinal, and entorhinal cortices in a nearly bilaterally symmetrical pattern. This pattern had filled in by the sixth stage 5 seizure. Induced labeling in cortical neurons was confined mainly to layer II...Continue Reading

References

Apr 15, 1977·The Journal of Comparative Neurology·J E Krettek, J L Price
Nov 25, 1975·The Journal of Comparative Neurology·V S Caviness
Aug 1, 1991·Brain Research. Molecular Brain Research·M ClarkT Nakajima
Apr 26, 1990·Nature·D SchubertW H Fischer
Jan 1, 1988·Trends in Neurosciences·J O McNamara
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Aug 1, 1972·Physiology & Behavior·A Molino, D C McIntyre
Nov 1, 1994·Trends in Neurosciences·O LindvallM Kokaia
Jun 1, 1995·Experimental Neurology·M KokaiaO Lindvall
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J Fann, P H Patterson
May 27, 1996·The Journal of Comparative Neurology·D C McIntyreW A Staines
Jul 29, 1996·Neuroreport·Y P TretterC Alzheimer
Dec 1, 1996·Epilepsy Research·M E Kelly, D C McIntyre
Feb 1, 1997·Journal of Neuroendocrinology·M FunabaK Torii
Jun 20, 1997·Brain Research·Y IwahoriN Nishiyama
Feb 14, 1998·The Journal of Biological Chemistry·C M ZimmermanL S Mathews
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·N T LiberatiX F Wang
May 13, 1999·The Journal of Endocrinology·D M de KretserD J Phillips
Feb 25, 2000·Brain Research. Molecular Brain Research·C R Plata-SalamánD C McIntyre
Jun 30, 2000·The Journal of Biological Chemistry·T López-RoviraF Ventura
Jul 11, 2000·Nature Medicine·M P Mattson
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A NanobashviliZ Kokaia
Feb 13, 2001·Trends in Neurosciences·D K BinderH E Scharfman

❮ Previous
Next ❯

Citations

Jun 22, 2013·Cytokine & Growth Factor Reviews·Francesco Elia MarinoElspeth Gold
Sep 9, 2006·Journal of Neurotrauma·David J PhillipsMaria C Morganti-Kossmann
May 28, 2008·Epilepsia·Dan C McIntyre, Krista L Gilby
Jun 23, 2009·Cell Communication and Signaling : CCS·Kunihiro TsuchidaKaoru Inokuchi
Oct 24, 2007·Journal of Molecular Neuroscience : MN·Patricia de GortariPatricia Joseph-Bravo
Jun 3, 2009·Stem Cells·Andrea Abdipranoto-CowleyBryce Vissel
Aug 8, 2007·Journal of Neurochemistry·Lana KupershmidtZeev Blumenfeld
Nov 9, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M NeufeldJ A Foster
Aug 22, 2006·Journal of the Neurological Sciences·Sandra EbertUwe Michel
Aug 15, 2006·Journal of Neuroimmunology·Xiaoxing MaBoris Sakic
Oct 11, 2005·Neurochemistry International·P de GortariP Joseph-Bravo
Dec 30, 2014·Frontiers in Neurology·David N Vaughan, Graeme D Jackson
Dec 13, 2018·Physiological Reviews·Enrrico BloiseFernando M Reis
Dec 4, 2019·Experimental Neurology·Heming ChengZhong Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.