Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases

Diagnostic Microbiology and Infectious Disease
Krisztina M Papp-WallaceMichael R Jacobs

Abstract

Avibactam is a novel β-lactamase inhibitor that restores the activity of otherwise hydrolyzed β-lactams against Gram-negative bacteria expressing different classes of serine β-lactamases. In the last decade, β-lactam-avibactam combinations were tested against a variety of clinical isolates expressing multiple commonly encountered β-lactamases. Here, we analyzed isogenic Escherichia coli strains expressing selected single β-lactamase genes that were not previously tested or were not characterized in an isogenic background. The activities of ceftazidime, ceftaroline, and aztreonam alone and in combination with 4 mg/L of avibactam, as well as comparator agents, were assessed against a unique collection of isogenic strains of E. coli carrying selected extended-spectrum, inhibitor-resistant, and/or carbapenem-hydrolyzing bla genes. When combined with avibactam, ceftazidime, ceftaroline, or aztreonam MICs were reduced for 91.4%, 80.0%, and 80.0% of isolates, respectively. The data presented add to our understanding of the microbiologic spectrum of these β-lactams with avibactam and serve as a reference for further studies.

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Citations

Jun 22, 2016·Future Medicinal Chemistry·David Yuxin WangChristopher J Schofield
Jul 11, 2016·Diagnostic Microbiology and Infectious Disease·Tommaso GianiGian Maria Rossolini
Jul 13, 2016·The Journal of Antimicrobial Chemotherapy·Sushmita D LahiriRichard A Alm
Nov 8, 2017·Infection·Felipe Francisco TuonMarcelo R Formigoni-Pinto
Apr 11, 2018·Antimicrobial Agents and Chemotherapy·Barbara GhiglioneGabriel Gutkind
Feb 16, 2018·Clinical Microbiology Reviews·Jesús Rodríguez-BañoAlvaro Pascual
Mar 2, 2016·Antimicrobial Agents and Chemotherapy·Sushmita D Lahiri, Richard A Alm
Mar 30, 2017·Antimicrobial Agents and Chemotherapy·Melina RuggieroPablo Power
Dec 17, 2015·Antimicrobial Agents and Chemotherapy·Jean-Marie PagèsWright W Nichols
Jan 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Ilias KaraiskosHelen Giamarellou
Mar 13, 2019·Antimicrobial Agents and Chemotherapy·Krisztina M Papp-WallaceCédric Jacqueline
Feb 6, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Karen Bush, Malcolm G P Page
Aug 8, 2020·Open Forum Infectious Diseases·Benjamin A PontefractS Eric Nybo
Jun 27, 2019·Antimicrobial Agents and Chemotherapy·Melina RuggieroPablo Power
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Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc

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