Sep 1, 1980

Activities of enzymes involved in amino-acid metabolism in developing rat placenta

European Journal of Biochemistry
X RemesarM Alemany

Abstract

Aspartate transaminase, alanine transaminase, glutamate dehydrogenase, arginase, serine dehydratase, tyrosine transaminase, glutamine synthetase, glutaminase and adenylate deaminase activities were measured in crude homogenates of 12, 19 and 21-day rat placentae. There is a considerable quantitative importance in enzymes able to produce free ammonia, such as adenylate deaminase and glutamate dehydrogenase, activity that progressively decrease with the age of placenta. The glutamine synthetase and tyrosine transaminase activities increase with age, while serine dehydratase decreases considerably and aspartate and alanine transaminase do not change practically. Arginase shows a maximum at 19, with lower 12 and 21-day activities. No measurable glutaminase activity has been found. The possible implications of the enzymes studied upon the ammonia-producing activity of rat placenta are discussed together with the relative decreasing role of placenta for the overall metabolic activity of the foetus, especially during the last phases of its development.

  • References12
  • Citations15

References

  • References12
  • Citations15

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Glud1
Fetal Structures
Entire Fetus
Enzymes, antithrombotic
Placenta Specimen
Aspartate
SDS gene
Glutaminase Activity
Glutamate-Ammonia Ligase

About this Paper

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