PMID: 6108212Sep 1, 1980Paper

Activities of enzymes involved in amino-acid metabolism in developing rat placenta

European Journal of Biochemistry
X RemesarM Alemany

Abstract

Aspartate transaminase, alanine transaminase, glutamate dehydrogenase, arginase, serine dehydratase, tyrosine transaminase, glutamine synthetase, glutaminase and adenylate deaminase activities were measured in crude homogenates of 12, 19 and 21-day rat placentae. There is a considerable quantitative importance in enzymes able to produce free ammonia, such as adenylate deaminase and glutamate dehydrogenase, activity that progressively decrease with the age of placenta. The glutamine synthetase and tyrosine transaminase activities increase with age, while serine dehydratase decreases considerably and aspartate and alanine transaminase do not change practically. Arginase shows a maximum at 19, with lower 12 and 21-day activities. No measurable glutaminase activity has been found. The possible implications of the enzymes studied upon the ammonia-producing activity of rat placenta are discussed together with the relative decreasing role of placenta for the overall metabolic activity of the foetus, especially during the last phases of its development.

References

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Citations

Aug 30, 2008·Veterinary Research Communications·Hélio C Manso FilhoMalcolm Watford
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·A PalouM Alemany
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·X RemesarM Pastor-Anglada
Jan 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N CarbóJ M Argilés
Jan 23, 2004·Biology of Reproduction·Jon T SelfGuoyao Wu
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jul 10, 1998·The Proceedings of the Nutrition Society·J C MatthewsD A Novak
Oct 1, 1982·Archives internationales de physiologie et de biochimie·L ArolaM Alemany
Mar 9, 2010·Placenta·A SwiecaK Kaletha
Apr 1, 1993·Early Human Development·J T DeSantoJ A Lemons
May 31, 2006·Reproduction, Nutrition, Development·William D ReesChristos Antipatis
Aug 15, 2001·American Journal of Physiology. Cell Physiology·D NovakM Beveridge
Jan 14, 2003·Experimental Biology and Medicine·M TimmermanT R H Regnault
Jun 1, 1994·Biochimica Et Biophysica Acta·L MazzantiG Biagini

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