PMID: 645360Mar 15, 1978

Activities of enzymes of the hexose monophosphate pathway in nervous system tumors induced by ethylnitrosourea

Acta Neuropathologica
M T Coleman, N Allen

Abstract

The activities of three enzymes of the hexose monophosphate pathway (HMP) were measured in frozen samples of rat cerebral cortex and ethylnitrosourea-induced tumors of the rat nervous system. Results show that in most tumors, adequate amounts of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH), and transketolase (TK) were present so as not to be rate-limiting for utilization of the HMP. When enzyme activites were expressed on the basis of fresh weight, TK was increased in most tumors as compared with cerebral cortex; G6PDH and 6PGDH were more variable, showing either higher or lower activities in tumors as compared to control. Tumors in general had a lower protein content than cerebral cortex. When activities were expressed in terms of this protein content, mean values for the dehydrogenases in all groups of tumors were higher than the average value in cortex, indicating that G6PDH and 6PGDH were spared in tumors relative to other proteins. TK activities in tumors, expressed in terms of cytosol protein were lower than or in the same range as cortex. Increased activities of HMP enzymes in some tumors indicated that the potential activity of the HMP in some (but not all) tumors of the nervous sy...Continue Reading

References

Jan 1, 1978·Journal of Neurochemistry·M T Coleman, N Allen
Dec 1, 1974·Cellular Immunology·A L SagoneS P Balcerzak
Nov 1, 1966·Journal of Neurochemistry·G M LehrerL C Scheinberg
Nov 28, 1967·Biochimica Et Biophysica Acta·R M GuerraM Villavicencio

Related Concepts

Metazoa
Insula of Reil
Ethylnitrosourea
Mixed Gliomas
Glucosephosphate Dehydrogenase
Neoplasms, Experimental
Nervous System Disorder
Phosphogluconate Dehydrogenase
Apotransketolase
Rats, Laboratory

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