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Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions

Proceedings of the National Academy of Sciences of the United States of America

Oct 23, 2008

A C Vallur, Nancy Maizels

Abstract

Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation. The enzyme has 5'-3' exonuclease, flap endonuclease, and weak RNaseH activity in vitro, but it has bee...read more

Mentioned in this Paper

DNA Repair Enzymes
Cytidine Deaminase
Immunoglobulin Class Switch Recombination
Heavy-Chain Mu Switch Region
Immunoglobulin Activity
Mismatch Repair
Endonuclease
Transcription, Genetic
Recombination, Genetic
EXO1 protein, human
Paper Details
References
  • References28
  • Citations13
123
  • References28
  • Citations13
12

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Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions

Proceedings of the National Academy of Sciences of the United States of America

Oct 23, 2008

A C Vallur, Nancy Maizels

PMID: 18940926

DOI: 10.1073/pnas.0805327105

Abstract

Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation. The enzyme has 5'-3' exonuclease, flap endonuclease, and weak RNaseH activity in vitro, but it has bee...read more

Mentioned in this Paper

DNA Repair Enzymes
Cytidine Deaminase
Immunoglobulin Class Switch Recombination
Heavy-Chain Mu Switch Region
Immunoglobulin Activity
Mismatch Repair
Endonuclease
Transcription, Genetic
Recombination, Genetic
EXO1 protein, human

Feeds With Similar Papers

HDR in Genome Engineering

Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.

Immunoglobulin Class Switching

Immunoglobulin class switching from igm to igg and iga is central to immunity against viruses and requires the activation of b cells by t cells via cd154 and cytokines. Discover the latest research on immunoglobulin class switching here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists

Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining

The Journal of Immunology : Official Journal of the American Association of ImmunologistsJanuary 19, 2011
Jennifer EcclestonErik Selsing
Paper Details
References
  • References28
  • Citations13
123
  • References28
  • Citations13
12

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