Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes

Reproduction : the Official Journal of the Society for the Study of Fertility
Tsutomu EndoHideaki Tojo

Abstract

The acetylation of nuclear core histone has been suggested to work as an epigenetic mark for transmitting gene expression patterns to daughter cells. Global histone deacetylations, presumably involved in the reprogramming of the gene expression, have been observed after germinal vesicle breakdown (GVBD) in a cell cycle-dependent manner during meiotic maturation of mouse and porcine oocytes, although the regulation mechanism of histone deacetylation has not been studied well. In the present study, we examined the involvement of a crucial cell-cycle-regulator, maturation-promoting factor (MPF), and a meiosis-related kinase, mitogen-activated protein kinase (MAPK), in the global histone deacetylation during porcine oocyte maturation. In order to know whether the activities of MPF and MAPK were required, or the breakdown of GV membrane was sufficient, for the global histone deacetylation observed after GVBD, we artificially destroyed the GV membrane of the porcine immature oocytes. The artificial GV destruction (AGVD) induced histone deacetylation without the activation of MPF and MAPK. This deacetylation after AGVD was not affected by an MPF inhibitor, roscovitine, or an inhibitor of protein synthesis, cycloheximide, but was compl...Continue Reading

References

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Mar 1, 2005·Molecular Reproduction and Development·Tsutomu EndoHideaki Tojo

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Citations

Jan 29, 2011·Zygote : the Biology of Gametes and Early Embryos·Byung Chul JeeShin Yong Moon
Feb 3, 2007·The Journal of Reproduction and Development·Lian-Sheng TangShu-Ying Wang
Jan 18, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Tsutomu EndoKunihiko Naito
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·P ComizzoliB S Pukazhenthi
Apr 16, 2016·Cell Death and Differentiation·P Ma, R M Schultz
Mar 15, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Zubing CaoYunhai Zhang

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