Activities of Pt(II) and Ru(III) triazole-pyrimidine complexes against Trypanosoma cruzi and T. brucei brucei

Rosa MagánM Sánchez-Moreno


We studied the biological activity of three newly synthesized metal complexes of triazole-pyrimidine derivatives that were previously observed to inhibit in vitro growth of epimastigotes of Trypanosoma cruzi and procyclic forms of Trypanosoma brucei brucei. We analyzed the possible inhibitory effect of these compounds on the synthesis of DNA, RNA and protein, ultrastructure and excretion of metabolites by these parasites. RNA synthesis was inhibited by all three complexes assayed. These complexes also led to anomalies of the main organelles (e.g. nucleus, kinetoplast and mitochondria). In addition, these complexes may be capable of altering the excretion of metabolites by the parasites.


Dec 15, 2012·Nature Reviews. Immunology·Michael S Diamond, Michael Farzan
Oct 6, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Ana B CaballeroChristoph Janiak
Oct 31, 2018·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Amer H TarawnehStephen J Cutler
Dec 7, 2018·Chemical Reviews·Yih Ching OngGilles Gasser

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