Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior

ELife
Daniel Christopher Haggerty, Daoyun Ji

Abstract

Visual cues exert a powerful control over hippocampal place cell activities that encode external spaces. The functional interaction of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet to be elucidated. Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (V1) of freely moving rats selectively fire at specific locations as animals run repeatedly on a track. The V1 location-specific activity leads hippocampal place cell activity both spatially and temporally. The precise activities of individual V1 neurons fluctuate every time the animal travels through the track, in a correlated fashion with those of hippocampal place cells firing at overlapping locations. The results suggest the existence of visual cortical neurons that are functionally coupled with hippocampal place cells for spatial processing during natural behavior. These visual neurons may also participate in the formation and storage of hippocampal-dependent memories.

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Citations

Jun 14, 2016·Royal Society Open Science·Magdalena Kautzky, Kay Thurley
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anish MitraMarcus E Raichle
Apr 14, 2018·Neural Computation·Shizhao LiuZhe Chen
Jun 19, 2018·Cerebral Cortex·Olivia V HaasKay Thurley
Aug 14, 2020·Neuron·Grigori GuitchountsDavid Cox
Jan 9, 2021·Translational Psychiatry·Suzanne N AveryStephan Heckers
Jan 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ye WangNancy Y Ip
Jan 17, 2020·Neuropsychologia·Arne D Ekstrom, Andrew P Yonelinas
May 23, 2017·Neuroscience Letters·Shauna M StarkCraig E L Stark
Dec 29, 2020·Current Opinion in Neurobiology·Tom Flossmann, Nathalie L Rochefort

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