Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum

FEBS Letters
David M Wyatt, Colin Berry

Abstract

A new aspartic proteinase from the human malaria parasite Plasmodium falciparum is able to hydrolyse human haemoglobin at a site known to be the essential primary cleavage site in the haemoglobin degradation pathway. Thus, plasmepsin IV may play a crucial role in this critical process which yields nutrients for parasite growth. Furthermore, synthetic inhibitors known to inhibit parasite growth in red cells in culture are able to inhibit the activity of this enzyme in vitro. As a result, plasmepsin IV appears to be a potential target for the development of new antiparasitic drugs.

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Citations

May 28, 2003·Journal of Molecular Biology·Nina Khazanovich BernsteinMichael N G James
Oct 11, 2003·Molecular and Biochemical Parasitology·John B DameTang Li
Mar 12, 2003·Bioorganic & Medicinal Chemistry·Karin OscarssonBertil Samuelsson
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Nov 11, 2021·Pharmaceutical Patent Analyst·Hermann Am Mucke

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