PMID: 6969627Dec 15, 1980Paper

Activity and isoenzymes of acid phosphatase in human B-cell lymphomas of low-grade malignancy: a novel aid in the classification of malignant lymphoma

Cancer
D SchmidtM R Parwaresch

Abstract

Activity and isoelectric focusing (IEF) pattern of lysosomal acid phosphatase (E.C.3.1.3.2.) were investigated in 55 cases of low-grade malignant B-cell lymphoma, classified as chronic B-lymphocytic leukemia (B-CLL), centroblastic/centrocytic follicular lymphoma (CB/CC), lymphoplasmacytic/lymphoplasmacytoid lymphoma (Immunocytoma, IC), and plasmacytoma (PC), applying the criteria of the Kiel classification. The results show (1) that the four lymphoma types present a characteristic range of enzyme activity in an increasing order: B-CLL, BC/CC, IC, and PC. B lymphocytes, germinal center cells, and plasmacytes are the main constituents of these lymphomas. This sequence might reflect one possible mode of B-cell transformation into plasmacytes traversing an amplification stage in germinal centers under normal conditions. (2) All cases showed the basic IEF pattern of normal B lymphocytes with 12 bands localized in three regions between pH 6.1 and 3.9. This finding supports the B-cell origin and the close phenotypical relationship among the investigated lymphomas. (3) The IEF patterns of B-CLL and CB/CC did not differ from that of normal B lymphocytes, whereas two additional isoenzymes were encountered in cases of IC and seven in PC; ...Continue Reading

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Citations

Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·H J RadzunM R Parwaresch
Aug 1, 1984·European Journal of Pediatrics·G Gaedicke, H G Drexler
Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·H J RadzunC Sundström
Oct 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg, D Brown
Jan 1, 1991·Leukemia & Lymphoma·S M GignacH G Drexler
Apr 1, 1982·Immunobiology·M R Parwaresch, H J Radzun
Sep 15, 1981·Cellular Immunology·H J RadzunJ W Wittke
Jan 1, 1985·Leukemia Research·H G DrexlerJ Minowada
Jan 1, 1985·British Journal of Haematology·J J HoffmannN Swaak-Lammers
Feb 15, 1983·International Journal of Cancer. Journal International Du Cancer·H J RadzunM Eissner
May 1, 1983·American Journal of Hematology·M B Van Der WeydenT E Gan
Jan 1, 1985·Critical Reviews in Oncology/hematology·P Rambotti, S Davis

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