Activity and loading influence the predicted bone remodeling around cemented hip replacements

Journal of Biomechanical Engineering
A S Dickinson

Abstract

Periprosthetic bone remodeling is frequently observed after total hip replacement. Reduced bone density increases the implant and bone fracture risk, and a gross loss of bone density challenges fixation in subsequent revision surgery. Computational approaches allow bone remodeling to be predicted in agreement with the general clinical observations of proximal resorption and distal hypertrophy. However, these models do not reproduce other clinically observed bone density trends, including faster stabilizing mid-stem density losses, and loss-recovery trends around the distal stem. These may resemble trends in postoperative joint loading and activity, during recovery and rehabilitation, but the established remodeling prediction approach is often used with identical pre- and postoperative load and activity assumptions. Therefore, this study aimed to evaluate the influence of pre- to postoperative changes in activity and loading upon the predicted progression of remodeling. A strain-adaptive finite element model of a femur implanted with a cemented Charnley stem was generated, to predict 60 months of periprosthetic remodeling. A control set of model input data assumed identical pre- and postoperative loading and activity, and was co...Continue Reading

References

Jan 1, 1987·Journal of Biomechanics·R HuiskesT J Slooff
Apr 1, 1984·Journal of Biomedical Materials Research·S Saha, S Pal
Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H WeinansJ O Galante
Dec 29, 2000·The Journal of Bone and Joint Surgery. British Volume·D S BarkerD W Howie
Apr 4, 2001·The Journal of Bone and Joint Surgery. British Volume·J M WilkinsonR Eastell
May 1, 2001·Computer Methods in Biomechanics and Biomedical Engineering·J M GarciaM Doblaré
May 22, 2003·Journal of Biomechanics·Elise F MorganTony M Keaveny
Mar 30, 2004·The Journal of Bone and Joint Surgery. British Volume·Y KishidaH Yoshikawa
Dec 18, 2004·Archives of Physical Medicine and Rehabilitation·Stan AjemianBarbara Loitz-Ramage
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J Mark WilkinsonRichard Eastell
Mar 31, 2005·Journal of Biomechanics·M O HellerG N Duda
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A W L TurnerW R Walsh
Mar 18, 2006·Clinical Biomechanics·Sanjay GuptaMark Taylor
Dec 15, 2006·Journal of Biomechanics·Andrew D SpeirsWilliam R Taylor
Apr 28, 2007·The Journal of Bone and Joint Surgery. British Volume·Y-H KimS-H Yoon
Nov 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yong-yun LianCamara-yagouba Fatou
May 29, 2008·Clinical Orthopaedics and Related Research·Ingrid B de GrootJan A Verhaar
Dec 4, 2008·International Orthopaedics·Georgios Digas, Johan Kärrholm
Aug 1, 2009·The Journal of Arthroplasty·Bernard N StulbergJayson D Zadzilka
Nov 3, 2009·Journal of Biomechanics·Piotr Kowalczyk
Dec 10, 2009·Acta Orthopaedica·Nick J CookeJames P Holland
May 7, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Alexander DickinsonMartin Browne
Oct 22, 2011·Clinical Orthopaedics and Related Research·Prakash ChandranJohn G Bradley
Apr 20, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthias LerchBernd A Behrens
Aug 7, 2012·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Michel P BonninDavid E Beverland
Jan 4, 2013·The Journal of Bone and Joint Surgery. American Volume·Raveen L JayasuriyaJeremy Mark Wilkinson
Feb 26, 2013·The Journal of Arthroplasty·Ajay MalviyaJim P Holland
Mar 19, 2013·The Journal of Arthroplasty·Margaret KuhnJohn C Clohisy
Jun 15, 2013·Journal of Biomechanics·Francis GallowayMark Taylor

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Citations

Jul 15, 2015·Journal of Biomechanics·Matthias A Verstraete, Jan Victor
Jun 27, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Souptick ChandaMartin Browne
Jul 6, 2020·Biomechanics and Modeling in Mechanobiology·Mehran AshrafiManuel Doblaré

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