Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus fumigatus Infection in Inoculated Young Quails

Mycopathologia
Piotr WlaźChris Rundfeldt

Abstract

Pulmonary aspergillosis is frequently reported in parrots, falcons, and other birds held in captivity. Inhalation is the main route of infection for Aspergillus fumigatus, resulting in both acute and chronic disease conditions. Itraconazole (ITRA) is an antifungal commonly used in birds, but its administration requires repeated oral dosing, and the safety margin is narrow. To investigate the efficacy of inhaled ITRA, six groups of ten young quails (Coturnix japonica) were inoculated intratracheally with 5 × 10(6) spores (3 groups) or 5 × 10(7) spores (3 groups). Animals were exposed to nebulized ITRA nanosuspension as 10 % suspension or 4 % suspension, once daily for 30 min, starting 2 h after inoculation for 6 days. Control groups were exposed to nebulized saline for the same period of time. Survival and clinical scores were evaluated, and animals were subjected to gross pathology. In control animals, aspergillosis resulted in systemic disease without pulmonary or air sac granulomas. Animals died from multiple organ failure. Inhalation of 10 % ITRA nanosuspension blocked lethality and prevented disease-related symptoms in the quails exposed to the low dose of spores, while the disease course in quails inoculated with the high-...Continue Reading

References

Feb 23, 1991·The Veterinary Record·V R Simpson, P R Euden
Jan 15, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hideyo YamaguchiToshiyuki Matsunaga
Aug 19, 2005·Journal of Wildlife Diseases·A BalseiroJ M Prieto
Aug 28, 2007·The Veterinary Record·V SchmidtM-E Krautwald-Junghanns
Mar 21, 2008·Journal of Avian Medicine and Surgery·Antonio Di SommaCelia Garcia-Martinez
Oct 1, 1990·Avian Pathology : Journal of the W.V.P.A·R J Julian, M Goryo
Sep 18, 2008·Avian Pathology : Journal of the W.V.P.A·L A BeernaertA Martel
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·L A BeernaertA Martel
Oct 19, 2010·Avian Pathology : Journal of the W.V.P.A·L A BeernaertA Martel
Oct 16, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chris RundfeldtPiotr Wlaź

❮ Previous
Next ❯

Citations

Aug 2, 2017·Avian Pathology : Journal of the W.V.P.A·Dominik FischerMichael Lierz
Jul 7, 2018·Frontiers in Microbiology·Daniel Elad, Esther Segal
Nov 2, 2018·Journal of Fungi·Daniel Elad
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Brenda KischkelCarlos P Taborda
Apr 4, 2021·Journal of Fungi·Pascal ArnéJacques Guillot
Apr 20, 2021·Expert Review of Respiratory Medicine·Sujit Kumar DebnathAbdelwahab Omri

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.