Activity dependent CAM cleavage and neurotransmission

Frontiers in Cellular Neuroscience
Katherine ConantSeung T Lim

Abstract

Spatially localized proteolysis represents an elegant means by which neuronal activity dependent changes in synaptic structure, and thus experience dependent learning and memory, can be achieved. In vitro and in vivo studies suggest that matrix metalloproteinase and adamalysin activity is concentrated at the cell surface, and emerging evidence suggests that increased peri-synaptic expression, release and/or activation of these proteinases occurs with enhanced excitatory neurotransmission. Synaptically expressed cell adhesion molecules (CAMs) could therefore represent important targets for neuronal activity-dependent proteolysis. Several CAM subtypes are expressed at the synapse, and their cleavage can influence the efficacy of synaptic transmission through a variety of non-mutually exclusive mechanisms. In the following review, we discuss mechanisms that regulate neuronal activity-dependent synaptic CAM shedding, including those that may be calcium dependent. We also highlight CAM targets of activity-dependent proteolysis including neuroligin and intercellular adhesion molecule-5 (ICAM-5). We include discussion focused on potential consequences of synaptic CAM shedding, with an emphasis on interactions between soluble CAM cleav...Continue Reading

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Citations

Mar 15, 2016·Frontiers in Cellular Neuroscience·Renée J Turner, Frank R Sharp
Nov 1, 2016·Journal of Neurochemistry·Behnam VafadariLeszek Kaczmarek
Nov 1, 2016·Molecular Biology of the Cell·Matylda RoszkowskaJoanna Dzwonek
Jan 8, 2016·Molecular Neurobiology·Ilona KondratiukTomasz Jaworski
Sep 23, 2018·Molecular Psychiatry·Michael A BembenKatherine W Roche
May 28, 2019·Frontiers in Molecular Neuroscience·Seham Alaiyed, Katherine Conant
Nov 18, 2020·Brain Research Bulletin·Mingyue WangDongdong Qin

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Methods Mentioned

BETA
pull down
glycosylation
co-immunoprecipiation

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