Activity-dependent changes in intracellular calcium in myenteric neurons

The American Journal of Physiology
M Hanani, N Lasser-Ross

Abstract

The spatial distribution and changes in intracellular calcium concentration ([Ca2+]i) in myenteric neurons were measured using fura 2 in the longitudinal muscle-myenteric plexus preparation from the guinea pig duodenum. These measurements were made simultaneously with intracellular voltage recordings. The generation of action potentials in the cell bodies of both S- and AH-type neurons increased [Ca2+]i in the processes and cell bodies. There was no measurable delay between the [Ca2+]i changes in the somata and the processes, indicating that these changes were caused by the spread of electrical signals and not by diffusion. The rate of Ca2+ removal was faster in the processes than in the somata, apparently due to the large surface-to-volume ratio in the former. In AH neurons, the [Ca2+]i transient was shorter than the duration of the after-spike hyperpolarization. It is concluded that the two main types of myenteric neurons possess voltage-gated Ca2+ channels in both somata and processes.

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Citations

May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·R BisschopsJ Tack
Nov 1, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pieter Vanden BergheTerence K Smith
May 16, 2001·Journal of Neurophysiology·F VogalisW A Kunze
Dec 15, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·J E WunderlichF L Christofi
Apr 14, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M HananiT Pannicke
Sep 25, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Timothy J HibberdNick J Spencer
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G HaschkeM Diener
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A De LaetJ-P Timmermans

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