PMID: 7526395Nov 22, 1994Paper

Activity-dependent current distributions in model neurons

Proceedings of the National Academy of Sciences of the United States of America
M SiegelL F Abbott

Abstract

The electrical activity of a neuron can affect its intrinsic physiological characteristics through a wide range of processes. We study a computer-simulated multicompartment model neuron in which channel density depends on local Ca2+ concentrations. This has three interesting consequences for the spatial distribution of conductances and the physiological behavior of the neuron: (i) the model neuron spontaneously develops a realistic, nonuniform distribution of conductances that is linked both to the morphology of the neuron and to the pattern of synaptic input that it receives, (ii) the response to synaptic input reveals a form of intrinsic localized plasticity that balances the synaptic contribution from dendritic regions receiving unequal stimulation, and (iii) intrinsic plasticity establishes a biophysical gain control that restores the neuron to its optimal firing range after synapses are strengthened by "Hebbian" long-term potentiation.

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Citations

Nov 26, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Eve Marder, Astrid A Prinz
Jan 7, 2009·Annals of Biomedical Engineering·Niranjan ChakravarthyLeon Iasemidis
Jun 1, 1996·Behavioural Brain Research·M MirmiranD F Swaab
Dec 1, 1995·Current Opinion in Neurobiology·R L Calabrese
Dec 1, 1995·Current Opinion in Neurobiology·E Marder, L F Abbott
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
May 19, 2011·Nature Reviews. Neuroscience·Arjen van Ooyen
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Timothy O'LearyEve Marder
Dec 29, 2000·Network : Computation in Neural Systems·K H Yang, K T Blackwell
Dec 23, 1998·Network : Computation in Neural Systems·K T BlackwellD L Alkon
Apr 8, 1998·Annual Review of Neuroscience·E Marder
Jul 27, 1999·Neural Computation·J GolowaschE Marder
Mar 31, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin M Crisp, Kenneth J Muller
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cengiz Günay, Astrid A Prinz
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott L HooperKevin H Hobbs
Jan 28, 2014·Brain Research Bulletin·Darrin H Brager, Daniel Johnston
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·E MarderJ Golowasch
Aug 10, 2011·The Journal of Physiology·Timothy O'Leary, David J A Wyllie
Jan 29, 2003·IEEE Transactions on Bio-medical Engineering·Jan Reinoud BuitenwegEnrico Marani
Jul 1, 2005·Journal of Integrative Neuroscience·M D Goldfinger
Aug 17, 1999·Nature Neuroscience·N S DesaiG G Turrigiano
Mar 24, 2006·Journal of Neurophysiology·Ithai Rabinowitch, Idan Segev
Jul 14, 2006·Journal of Neurophysiology·Clifton C Rumsey, L F Abbott
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Jun 4, 2020·Journal of Neurophysiology·Erik J Peterson, Bradley Voytek
Oct 1, 2020·Scientific Reports·Srinivas Gorur-ShandilyaTimothy O'Leary
Oct 29, 2000·Science·I Segev, M London

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