Activity-dependent expression of miR-132 regulates immediate-early gene induction during olfactory learning in the greater short-nosed fruit bat, Cynopterus sphinx

Neurobiology of Learning and Memory
Murugan MukilanKoilmani Emmanuvel Rajan

Abstract

The activity-dependent expression of immediate-early genes (IEGs) and microRNA (miR)-132 has been implicated in synaptic plasticity and the formation of long-term memory (LTM). In the present study, we show that olfactory training induces the expression of IEGs (EGR-1, C-fos, C-jun) and miR-132 at similar time scale in olfactory bulb (OB) of Cynopterus sphinx. We examined the role of miR-132 in the OB using antisense oligodeoxynucleotide (AS-ODN) and demonstrated that a local infusion of AS-ODN in the OB 2h prior to training impaired olfactory memory formation in C. sphinx. However, the infusion of AS-ODN post-training did not cause a deficit in memory formation. Furthermore, the inhibition of miR-132 reduced the olfactory training-induced expression of IEGs and post synaptic density protein-95 (PSD-95) in the OB. Additionally, we show that miR-132 regulates the activation of calcium/calmodulin-dependent protein kinase-II (CaMKII) and cAMP response element binding protein (CREB), possibly through miR-148a. These data suggest that olfactory training induces the expression of miR-132 and IEGs, which in turn activates post-synaptic proteins that regulate olfactory memory formation.

References

Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M GuthrieC Gall
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Aug 25, 2001·Annual Review of Neuroscience·R Yuste, T Bonhoeffer
Jan 11, 2002·Reviews in the Neurosciences·E Thiels, E Klann
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·J Paige Adams, J David Sweatt
Feb 21, 2004·Nature Reviews. Neuroscience·Gareth M Thomas, Richard L Huganir
Jun 2, 2005·Behavioural Brain Research·Daniela D PollakGert Lubec
Nov 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ngan VoSoren Impey
Jun 14, 2006·Journal of Chemical Ecology·Francisco SánchezBerry Pinshow
Dec 7, 2006·Biology Letters·John M Ratcliffe, Hannah M Ter Hofstede
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ingrid EhrlichRoberto Malinow
Oct 13, 2007·Neurobiology of Learning and Memory·Teiko MiyashitaJohn F Guzowski
Jun 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gary A WaymanSoren Impey
May 22, 2009·Neuromolecular Medicine·Neil R Smalheiser, Giovanni Lugli
Feb 18, 2010·International Journal of Molecular Sciences·Sheng PengBingxu Ren
Apr 29, 2011·Neurobiology of Learning and Memory·Timothy W BredyJohn S Mattick
Sep 6, 2011·Nature Neuroscience·Paola TogniniTommaso Pizzorusso
Nov 9, 2011·The International Journal of Biochemistry & Cell Biology·Paola Tognini, Tommaso Pizzorusso
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eva BenitoAngel Barco
Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Brooke H MillerClaes Wahlestedt
Mar 1, 2012·Nucleic Acids Research·Anaïs WanetPatricia Renard
Mar 23, 2012·Trends in Neurosciences·Heh-In Im, Paul J Kenny
Jun 19, 2012·Brain Structure & Function·Katelin F HansenKarl Obrietan
Aug 1, 2012·The European Journal of Neuroscience·Helen L ScottJames B Uney
Sep 25, 2012·Behavioural Brain Research·R CharraG Coureaud
Nov 20, 2012·Neurobiology of Aging·Monica K ChawlaCarol A Barnes
Feb 23, 2013·Behavioural Brain Research·Kirstin ReineckeThomas Schiffelholz
Mar 20, 2013·BioMed Research International·Xiaolei LiWeidong Han
Apr 8, 2014·European Journal of Pharmacology·Ziwen WangJiqiang Zhang
Apr 20, 2014·Neuron·Daniel MeyerVolker Scheuss

❮ Previous
Next ❯

Citations

Apr 28, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julia Hernandez-RappSébastien S Hébert
Sep 1, 2017·Nature Reviews. Neuroscience·Evgenia Salta, Bart De Strooper
Jun 2, 2018·Scientific Reports·A HadarD Gurwitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.