Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium

Chemical Senses
Qiang WangTimothy S McClintock

Abstract

Activity-dependent processes are important to olfactory sensory neurons (OSNs) in several ways, such as cell survival and the specificity of axonal convergence. The identification of activity-dependent mRNAs has contributed to our understanding of OSN axon convergence, but has revealed surprisingly little about other processes. Published studies of activity-dependent mRNAs in olfactory mucosae overlap poorly, but by combining these agreements with meta-analysis of existing data we identify 443 mRNAs that respond to methods that alter OSN activity. Three hundred and fifty of them are expressed in mature OSNs, consistent with the expectation that activity-dependent responses are cell autonomous and driven by odor stimulation. Many of these mRNAs encode proteins that function at presynaptic terminals or support electrical activity, consistent with hypotheses linking activity dependence to synaptic plasticity and energy conservation. The lack of agreement between studies is due largely to underpowered experiments. In addition, methods used to alter OSN activity are susceptible to indirect or off-target effects. These effects deserve greater attention, not only to rigorously identify OSN mRNAs that respond to altered OSN activity, b...Continue Reading

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Dec 6, 2018·Nature Communications·Carl van der LindenStephen W Santoro
Jun 18, 2019·Drug Metabolism Reviews·Jean-Marie HeydelFabrice Neiers
Dec 29, 2020·Molecular and Cellular Neurosciences·Elizabeth A CoreyBarry W Ache
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