Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal output

Proceedings of the National Academy of Sciences of the United States of America
Winnie WefelmeyerJuan Burrone

Abstract

The axon initial segment (AIS) is a structure at the start of the axon with a high density of sodium and potassium channels that defines the site of action potential generation. It has recently been shown that this structure is plastic and can change its position along the axon, as well as its length, in a homeostatic manner. Chronic activity-deprivation paradigms in a chick auditory nucleus lead to a lengthening of the AIS and an increase in neuronal excitability. On the other hand, a long-term increase in activity in dissociated rat hippocampal neurons results in an outward movement of the AIS and a decrease in the cell's excitability. Here, we investigated whether the AIS is capable of undergoing structural plasticity in rat hippocampal organotypic slices, which retain the diversity of neuronal cell types present at postnatal ages, including chandelier cells. These interneurons exclusively target the AIS of pyramidal neurons and form rows of presynaptic boutons along them. Stimulating individual CA1 pyramidal neurons that express channelrhodopsin-2 for 48 h leads to an outward shift of the AIS. Intriguingly, both the pre- and postsynaptic components of the axo-axonic synapses did not change position after AIS relocation. We ...Continue Reading

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Citations

Oct 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kate E Hoy, Paul B Fitzgerald
Oct 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Winnie Wefelmeyer, Juan Burrone
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