Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease

Journal of Proteomics
Ming-Hui YangYu-Chang Tyan

Abstract

Alzheimer's disease (AD) is the most common cause of dementia of late life. To enhance our understanding of AD proteome, the serum proteins were analyzed using two-dimensional gel electrophoresis (2DE) combined with nano-high performance liquid chromatography electrospray ionization tandem mass spectrometry (nano-HPLC-ESI-MS/MS) followed by peptide fragmentation patterning. In this study, six protein spots with differential expression were identified. Five up-regulated proteins were identified as actin, apolipoprotein A-IV (Apo A-IV), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), alpha-1-antitrypsin (AAT), and antithrombin-III (AT-III); one protein, activity-dependent neuroprotector homeobox protein (ADNP) was down-regulated in AD patients. These proteins with differential expression in the serum may serve as potential indicators of AD. Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD.

References

Oct 1, 1991·Brain Research. Molecular Brain Research·C F DeschepperM C Lapointe
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PandeyH F Lodish
Dec 5, 2000·Regulatory Peptides·I ZemlyakI Gozes
Dec 18, 2001·Nephron·A MontanelliV Grassi
Sep 17, 2002·Briefings in Bioinformatics·Claire O'DonovanRolf Apweiler
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael F WilkemeyerMichael E Charness
Jun 26, 2003·Nucleic Acids Research·Elisabeth GasteigerAmos Bairoch
Oct 16, 2004·Clinical Chemistry·Zheng WangEric T Fung
Dec 14, 2004·Amino Acids·M FountoulakisH Langen
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara Lisowska-Myjak
Feb 1, 2005·Proteomics·Yu-Chang TyanPao-Chi Liao
Sep 2, 2006·Journal of Proteome Research·Eleftherios P Diamandis
Oct 31, 2006·Brain : a Journal of Neurology·A HyeS Lovestone
Mar 3, 2007·The Journal of Clinical Investigation·Tomas VaisarJay W Heinecke
Apr 21, 2007·Analytical and Bioanalytical Chemistry·Ming-Hui YangMing-Chen Wang
Aug 28, 2007·The Journal of Pharmacology and Experimental Therapeutics·Inna Vulih-ShultzmanIllana Gozes
Dec 7, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sushmita RoyJames L Rubenstein
Oct 22, 2008·Neurobiology of Disease·Min ShiJing Zhang
Nov 18, 2008·Neurobiology of Disease·Rebecca Craig-SchapiroDavid M Holtzman
Jan 6, 2009·BMC Neuroscience·Illana GozesInbar Piltzer
Oct 21, 2009·CNS Neuroscience & Therapeutics·Philine SchneiderKatharina Buerger
Nov 1, 2007·Proteomics. Clinical Applications·Yan HuDavid M Holtzman
May 1, 2007·Proteomics. Clinical Applications·Pao-Chi LiaoYu-Min Kuo
Feb 12, 2011·Acta Neuropathologica·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Jul 31, 2013·PloS One·Sungeun KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Apr 29, 2014·PloS One·Wenwen LuXiaoliang Wang
Oct 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Chang TyanPao-Chi Liao
Oct 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Chang TyanShiang-Bin Jong
Oct 4, 2014·Peptides·Vladimir V KorolkovSaul J B Tendler
Nov 28, 2014·International Journal of Molecular Sciences·Qiao LinJie Gao
Jan 28, 2016·Journal of Molecular Neuroscience : MN·Illana GozesAnat Idan-Feldman
Dec 5, 2015·Frontiers in Neurology·Alison L BairdSimon Lovestone
Oct 5, 2015·Journal of Affective Disorders·Xiaohua LiuTiffany A Greenwood
Jun 20, 2013·BioMed Research International·Ming-Hui YangYu-Chang Tyan
May 9, 2014·International Journal of Molecular Sciences·Yahui LiuYulin Deng
Sep 25, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shlomo SragovichIllana Gozes
Nov 6, 2013·International Journal of Geriatric Psychiatry·Miwa NoguchiManae S Kurokawa
Sep 20, 2019·Translational Psychiatry·Shlomo SragovichIllana Gozes
Nov 10, 2017·International Journal of Genomics·Jesús Espinal-EnríquezEnrique Hernández-Lemus
Oct 22, 2019·Frontiers in Cellular Neuroscience·Yanina Ivashko-Pachima, Illana Gozes
Nov 19, 2015·Frontiers in Aging Neuroscience·Illana Gozes, Yanina Ivashko-Pachima
Aug 30, 2017·Molecular Medicine Reports·Qinghong ZengHaojiang Zhang
Apr 9, 2019·Journal of Alzheimer's Disease : JAD·Xiaowen ShiKoji Abe
Jun 27, 2020·Journal of Molecular Neuroscience : MN·Yanina Ivashko-Pachima, Illana Gozes
Dec 3, 2016·Frontiers in Cellular Neuroscience·Yu-Chih LinGene J Blatt
Oct 31, 2017·Journal of Molecular Neuroscience : MN·Illana GozesKina Höglund
Jul 20, 2019·Nature Communications·Robert F HillaryRiccardo E Marioni
Sep 11, 2020·Journal of Neurochemistry·Jessica Diniz PereiraKarina Braga Gomes
Aug 30, 2021·Molecular Neurodegeneration·M Mahafuzur Rahman, Christofer Lendel

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.