Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?

Journal of Molecular Neuroscience : MN
I Gozes, D E Brenneman

Abstract

To understand and intervene in neuronal cell death, intensive investigations have been directed at the discovery of intracellular and extracellular factors that provide natural neuroprotection. This goal has fundamental importance for both rational strategies for the treatment of neurodegenerative diseases and also the delineation of molecular mechanisms that regulate nervous system differentiation and growth. We have discovered a potential interface among these fields of research with activity-dependent neurotrophic factor (ADNF), a protein containing sequence homologies to intracellular stress proteins that is found in the extracellular milieu of astroglial cells incubated with the neuropeptide vasoactive intestinal peptide (VIP). Femtomolar concentrations of ADNF and a short peptide sequence derived from it (a peptidergic active site) protected neurons from death associated with a broad range of toxins, including those related to Alzheimer's disease, the human immunodeficiency virus, excito-toxicity, and electrical blockade. Because the activity of the protein was mimicked by a short peptide fragment, this peptide is now proposed as a lead compound for drug development against neurodegeneration.

References

Jan 1, 1979·Differentiation; Research in Biological Diversity·R Levi-Montalcini
Jan 1, 1991·Annual Review of Microbiology·J Zeilstra-RyallsC Georgopoulos
Feb 1, 1992·Journal of Neurochemistry·D E BrennemanI Gozes
Jan 1, 1990·Brain Research. Developmental Brain Research·D E BrennemanP G Nelson
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D E BrennemanP G Nelson
Dec 1, 1990·Bioscience Reports·G M AlderC A Pasternak
Mar 1, 1990·Journal of Neuroscience Research·D E BrennemanL M Bowers
Jul 1, 1987·Brain Research·I GozesW H Rostène
Jan 1, 1989·Journal of Molecular Neuroscience : MN·I GozesY Koch
Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M BodnerI Gozes
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·J J Legros, M Timsit-Berthier
Jan 1, 1988·Annals of the New York Academy of Sciences·V Mutt
Jan 1, 1988·The Journal of Clinical Investigation·S MinotaJ Winfield
Jan 1, 1988·Neuroendocrinology·I GozesE Giladi
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D E Brenneman, L E Eiden
Jun 1, 1987·The Journal of Cell Biology·D E BrennemanG L Westbrook
Jan 1, 1985·Peptides·D E BrennemanR E Siegel
Oct 13, 1995·Biochemical and Biophysical Research Communications·M McMillianG Bing
Aug 1, 1994·Trends in Neurosciences·S I Said
Jan 23, 1995·Behavioural Brain Research·J P Huston, R U Hasenöhrl
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D E BrennemanT W Phillips
Jan 1, 1994·Journal of Molecular Neuroscience : MN·G LillingI Gozes
Jan 15, 1993·Brain Research·J N CrawleyT Bartfai
Feb 1, 1995·The European Journal of Neuroscience·C D Nobes, A M Tolkovsky

❮ Previous
Next ❯

Citations

Mar 3, 1998·Journal of Molecular Neuroscience : MN·O Ashur-FabianI Gozes
Jul 9, 2008·Journal of Molecular Neuroscience : MN·Illana Gozes
Jun 16, 2009·Neurotoxicity Research·Howard J Federoff
Dec 5, 2000·Regulatory Peptides·I ZemlyakI Gozes
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·I GozesM Fridkin
Jan 6, 2009·BMC Neuroscience·Illana GozesInbar Piltzer
Jan 28, 2016·Journal of Molecular Neuroscience : MN·Illana GozesAnat Idan-Feldman
Mar 17, 2007·Pharmacology & Therapeutics·Illana Gozes
Dec 3, 2016·Scientific Reports·Shmma QuraisheAmritpal Mudher
Oct 28, 2016·Neurological Research·Guangxiu Deng, Lan Jin
May 20, 2000·Biotechnology & Genetic Engineering Reviews·A R CoatesP Mascagni
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Jul 21, 1998·Annals of the New York Academy of Sciences·I R Brown, I Gozes
Feb 17, 2000·Annals of the New York Academy of Sciences·I GozesD E Brenneman
Mar 10, 2004·The Journal of Pharmacology and Experimental Therapeutics·Douglas E BrennemanIllana Gozes
Feb 24, 2001·Annals of the New York Academy of Sciences·I GozesD E Brenneman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.