Activity-dependent regulation of dopamine content in the olfactory bulbs of naris-occluded rats

Neuroscience
B D PhilpotP C Brunjes

Abstract

Several lines of evidence strongly suggest that reduced olfactory nerve activity results in decreased bulb dopamine content. In the present study, high performance liquid chromatography with electrochemical detection was used to assess catecholamine levels in bulbs from postnatal day 60 rats that had undergone either unilateral naris cautery or a sham surgery on day 30. Thirty days of odor deprivation dramatically reduced dopamine and dihydroxyphenylacetic acid levels in functionally-deprived bulbs (ipsilateral to occluded nares) as compared to contralateral controls, while norepinephrine and dihydroxyphenylglycol levels were unchanged. The loss of dopamine was more severe in medial as compared to lateral aspects of experimental bulbs, while the loss of dihydroxyphenylacetic acid was similar on the two sides. To test directly the hypothesis that afferent activity regulates dopamine and dihydroxyphenylacetic acid content, 1 h of high frequency tetanic nerve stimulation was provided to the rostral-medial olfactory nerve layer in deprived olfactory bulbs, and catecholamine levels were assessed from 6 to 192 h later. Partial and temporary recovery of dopamine was observed in medial aspects of the bulb when rats were examined 96 h l...Continue Reading

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Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Brady J MaherGary L Westbrook
Jan 30, 2004·Learning & Memory·Donald A WilsonRegina M Sullivan
Jan 22, 2015·The Journal of Physiology·Yaniv CohenDonald A Wilson
Jun 12, 2008·European Journal of Pharmacology·Fidelis E AtianjohJean Lud Cadet
Oct 30, 2004·The Journal of Comparative Neurology·Sachiko Saino-SaitoHarriet Baker
Sep 29, 2004·The Journal of Comparative Neurology·Jennifer M MirichPeter C Brunjes
Sep 13, 2014·The European Journal of Neuroscience·Sara BonzanoSilvia De Marchis
Oct 26, 2005·Experimental Neurology·Beate WinnerJürgen Winkler
Dec 25, 2002·Journal of Neurobiology·Kathryn A Hamilton, David M Coppola
Apr 12, 2007·The European Journal of Neuroscience·C GómezJ R Alonso
Jun 4, 2013·Neuroscience·J T CorthellP Q Trombley
Nov 28, 2002·The Journal of Comparative Neurology·Jennifer M MirichPeter C Brunjes
May 19, 2006·Journal of Neurophysiology·Daniel B Rubin, Thomas A Cleland
Jul 11, 2020·Current Allergy and Asthma Reports·Concepció MarinJoaquim Mullol

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