Activity-dependent regulation of nuclear respiratory factor-1, nuclear respiratory factor-2, and peroxisome proliferator-activated receptor gamma coactivator-1 in neurons

Neuroreport
Huan Ling Liang, M Wong-Riley

Abstract

Nuclear respiratory factor-1 and nuclear respiratory factor-2 activate the transcription of several respiratory chain enzymes and are prime candidates for bigenomic coordinated regulation of cytochrome oxidase subunit genes from the two genomes. Peroxisome proliferator-activated receptor gamma coactivator 1 is a proposed coactivator of nuclear respiratory factor-1 and nuclear respiratory factor-2-dependent transcription, but its significance and function in neurons are unknown. Our current study indicates that nuclear respiratory factor-1, nuclear respiratory factor-2, and peroxisome proliferator-activated receptor gamma coactivator-1 are expressed in rat visual cortical neurons, and that neuronal activity directly regulates the protein and mRNA expressions of these factors after functional inactivation in vivo and in vitro. Changes in peroxisome proliferator-activated receptor gamma coactivator-1 preceded those of nuclear respiratory factor-1 and nuclear respiratory factor-2, suggesting that it may be the prime sensor of neuronal activity and its energy demand.

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Citations

Aug 30, 2008·Stroke; a Journal of Cerebral Circulation·Wei YinJun Chen
Aug 9, 2007·Genome Biology·Adrienne E McKeePamela A Silver
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K LucasRita M Cowell
May 26, 2009·Experimental Neurology·Janet M Dubinsky
Mar 6, 2007·The Journal of Comparative Neurology·Rita Marie CowellJames W Russell
Dec 22, 2010·Biochimica Et Biophysica Acta·Shilpa S Dhar, Margaret T T Wong-Riley
Dec 14, 2007·The Journal of Biological Chemistry·Shilpa S DharMargaret T T Wong-Riley

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