Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus.

The Journal of Physiology
Aude PanatierS H Oliet

Abstract

Activity-dependent long-term synaptic changes were investigated at glutamatergic synapses in the supraoptic nucleus (SON) of the rat hypothalamus. In acute hypothalamic slices, high frequency stimulation (HFS) of afferent fibres caused long-term potentiation (LTP) of the amplitude of AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) recorded with the whole-cell patch-clamp technique. LTP was also obtained in response to membrane depolarization paired with mild afferent stimulation. On the other hand, stimulating the inputs at 5 Hz for 3 min at resting membrane potential caused long-term depression (LTD) of excitatory transmission in the SON. These forms of synaptic plasticity required the activation of NMDA receptors since they were abolished in the presence of D-AP5 or ifenprodil, two selective blockers of these receptors. Analysis of paired-pulse facilitation and trial-to-trial variability indicated that LTP and LTD were not associated with changes in the probability of transmitter release, thereby suggesting that the locus of expression of these phenomena was postsynaptic. Using sharp microelectrode recordings in a hypothalamic explant preparation, we found that HFS also generates LTP at functionally defined gl...Continue Reading

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Citations

Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhiye ZhuangDaniel J Liebl
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher G ThomasJeffrey S Diamond
Jul 27, 2014·The Journal of Physiology·Ariane GagnonCharles W Bourque
Mar 30, 2010·Frontiers in Neuroendocrinology·Karl J IremongerJaideep S Bains
May 21, 2009·Journal of Neuroendocrinology·A Panatier
Aug 2, 2011·Journal of Neuroscience Research·Claire-Marie VacherHélène Hardin-Pouzet
Dec 15, 2010·The European Journal of Neuroscience·Jaclyn I Wamsteeker, Jaideep S Bains
Jul 22, 2014·Journal of Affective Disorders·Bárbara AriasLourdes Fañanás
Feb 5, 2013·Autonomic Neuroscience : Basic & Clinical·J E Stern, J A Filosa
Jun 27, 2009·Neuron·J Brent KuzmiskiJaideep S Bains
Jul 29, 2008·Progress in Brain Research·Reza Sharif-NaeiniCharles W Bourque
Dec 8, 2009·Trends in Neurosciences·Masha Prager-Khoutorsky, Charles W Bourque
Mar 2, 2010·Nature Neuroscience·Eric Trudel, Charles W Bourque
Dec 29, 2011·Endocrinology·Ronald St-LouisHélène Hardin-Pouzet
Jul 22, 2006·The Journal of Physiology·Grant R J Gordon, Jaideep S Bains
Mar 18, 2016·Physiological Reviews·Ivan IzquierdoJociane C Myskiw
Apr 27, 2019·Frontiers in Synaptic Neuroscience·Silvana Valtcheva, Laurent Venance
Mar 18, 2021·Cell Reports·David I LeviCharles W Bourque

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