Activity in varicosities within the myenteric plexus between and during the colonic migrating motor complex in the isolated murine large intestine.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Peter O BayguinovT K Smith

Abstract

  Neuronal communication within the myenteric plexus occurs when action potentials along nerve fibers produce Ca(2+) transients in varicosities leading to exocytosis of vesicles and neurotransmitters release. We used Ca(2+) transients in varicosities to monitor action potential activity in myenteric nerve pathways both between and during the colonic migrating motor complex (CMMC) in the isolated murine colon.   Strips of longitudinal muscle were removed to reveal the myenteric ganglia, which were then loaded with Fluo-4.   Many varicosities, including synaptotagmin 1 labeled varicosities, exhibited ongoing Ca(2+) transients (duration of unitary Ca(2+) transient 3.9 s). Between CMMCs, varicosities fired at a frequency of 0.6 Hz, which correlated with spontaneous inhibitory junction potentials in the circular muscle, suggesting they were mainly in inhibitory nerve pathways. During a CMMC other previously quiescent varicosities fired at 1.3 Hz (max. 2.0 Hz) for the duration (24 s) of the CMMC, suggesting they were on excitatory nerve pathways. Activity in varicosities was correlated with Ca(2+) transient responses in a number of neurons. Some varicosities appeared to release an inhibitory neurotransmitter that reduced activity in ...Continue Reading

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Citations

Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dante J HerediaTerence K Smith
May 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Apr 25, 2021·Progress in Neurobiology·Matthew J Broadhead, Gareth B Miles

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