Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.

Journal of Applied Physiology
Kristen A BaltgalvisJames A Carson

Abstract

Criteria for diagnosing cachexia in adults include unintentional loss in body weight, decreased strength, fatigue, anorexia, and low muscle mass. Cachexia is also associated with systemic inflammation, altered metabolism, and anemia. The Apc(Min/+) mouse is a model of cachexia directly related to intestinal tumor burden and subsequent chronic inflammation. These mice also demonstrate muscle weakness, fatigue, decreased volitional activity, and elevated circulating IL-6 levels. The purpose of this study was to determine the time course of changes in physical activity and their relationship to anemia, muscle apoptosis, and muscle mass and body mass loss during cachexia. A subset of male Apc(Min/+) mice were given access to voluntary activity wheels from 5 to 26 wk of age, while sedentary male Apc(Min/+) mice were housed in cages lacking wheels. At the study's end mice were stratified by cachectic symptoms. Severely cachectic mice had decreased wheel running performance at 15 wk of age, while anemia and body weight loss were not present until 18 wk of age. Severely cachectic mice had lower hemoglobin levels compared with mildly cachectic mice at 13, 18, and 22 wk of age. Severely cachectic mice also demonstrated threefold more BCL...Continue Reading

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Citations

Sep 28, 2010·Exercise and Sport Sciences Reviews·James A Carson, Kristen A Baltgalvis
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Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James P WhiteJames A Carson
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Mar 13, 2014·Journal of Applied Physiology·Melissa J PuppaJames A Carson
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Feb 14, 2020·Expert Opinion on Drug Discovery·Tsuyoshi SuzukiJochen Springer
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