Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris

Dermatology : International Journal for Clinical and Investigative Dermatology
D M ThiboutotG Lin

Abstract

Linoleic acid deficiency, interleukin 1, retinoids and androgens have been implicated as causative factors in the follicular hyperkeratinization seen in acne. The goal of this study was to test the hypothesis that more androgens are produced in follicles of acne subjects compared to subjects without acne. Thirty-four subjects (males and females with and without acne) were studied. The activity of 5 alpha-reductase (5 alpha-R) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) was determined in keratinocytes cultured from the infrainfundibulum and epidermis. Mean enzyme activities were slightly higher in the acne groups compared to the groups without acne, but differences were not statistically significant, perhaps due to limitations of this in vitro model. The activity of both 5 alpha-R and 17 beta-HSD was significantly greater in infrainfundibular keratinocytes compared to epidermal keratinocytes in all subject groups. 17 beta-HSD activity was 2.5- to 7-fold greater than the activity of 5 alpha-R in infrainfundibular keratinocytes. The regulation of 17 beta-HSD by endogenous factors may be important in determining the directional activity of 17 beta-HSD and hence the local concentration of testosterone within the infrainfu...Continue Reading

Citations

Jan 29, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C C Zouboulis
Apr 12, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T JansenG Plewig
Mar 22, 2005·Journal of Cutaneous Medicine and Surgery·Yves Poulin
Jan 25, 2008·Gender Medicine·Harry Dao, Rebecca A Kazin
Dec 6, 2000·The Australasian Journal of Dermatology·J J Chan, J B Rohr
Apr 9, 2005·The New England Journal of Medicine·William D James
Jul 21, 2012·Cutaneous and Ocular Toxicology·Ihsan UstunCumali Gokce
Feb 20, 2009·The Journal of Investigative Dermatology·Bodo C MelnikChristos C Zouboulis
Mar 11, 2008·La Presse médicale·Gwenaelle Dumont-Wallon, Brigitte Dréno
May 23, 2008·International Journal of Cosmetic Science·H E KnaggsO H Mills
Nov 13, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bodo Melnik, Gerd Schmitz
Jul 16, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·Y PangH D Chen
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·B Shaheen, M Gonzalez
Jun 19, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E TrakakisD Kassanos
Nov 4, 2000·Dermatologic Clinics·W Abramovits, A Gonzalez-Serva
Aug 5, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Abdullah AzmahaniHironobu Sasano
Jun 2, 2014·Journal of the American Academy of Dermatology·Eubee Baughn KooAlexandra Boer Kimball
May 14, 2011·Postgraduate Medicine·Peter HsuRobert T Brodell
May 4, 2010·Dermato-endocrinology·Bodo C Melnik
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Jan 4, 2019·International Journal of Dermatology·Allison C HuNatasha A Mesinkovska
Oct 21, 2000·Endocrine Reviews·A Slominski, J Wortsman
Aug 29, 2014·The Journal of Biological Chemistry·Eunbi KoYun Soo Bae
Sep 5, 2006·Pediatrics·Andrea L Zaenglein, Diane M Thiboutot

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