Activity of 5-episisomicin compared with that of other aminoglycosides.

Antimicrobial Agents and Chemotherapy
K P Fu, H C Neu

Abstract

5-Episisomicin, a semisynthetic aminoglycoside, has been shown to inhibit many members of the Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus. At a concentration of 3.1 mug/ml, more than 90% of Escherichia coli, Klebsiella pneumoniae, Enterobacter, Citrobacter, indole-positive Proteus, and Providencia were inhibited. 5-Episisomicin had activity against S. aureus, E. coli, Klebsiella, Enterobacter, and Citrobacter similar to gentamicin and netilmicin. It had activity similar to amikacin and netilmicin against many gentamicin-resistant bacteria. The activity of 5-episisomicin was greatest at an alkaline pH and in medium of low magnesium content. Synergy of 5-episisomicin and carbenicillin was found to occur most often against Pseudomonas.

References

Sep 1, 1976·Antimicrobial Agents and Chemotherapy·K P Fu, H C Neu
Jan 1, 1975·Methods in Enzymology·M J Haas, J E Dowding
Feb 1, 1978·The Journal of Antibiotics·B K LeeM J Weinstein
Jan 1, 1978·Antimicrobial Agents and Chemotherapy·J A WaitzP J Chiu
Aug 1, 1976·The Journal of Infectious Diseases·H C Neu
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·K P Fu, H C Neu
Dec 1, 1974·The Journal of Antibiotics·R T TestaM J Weinstein
Jan 1, 1973·Annual Review of Biochemistry·R Benveniste, J Davies
Jan 1, 1972·Antimicrobial Agents and Chemotherapy·J Dienstag, H C Neu

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Citations

Mar 1, 1980·Antimicrobial Agents and Chemotherapy·R WiseK A Bedford
May 16, 2007·Bioorganic & Medicinal Chemistry Letters·Yukiko HiraiwaDaishiro Ikeda
Aug 22, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·E Azucena, S Mobashery

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