PMID: 8953425Nov 1, 1996Paper

Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies

Journal of Ethnopharmacology
Y R Sohni, R M Bhatt

Abstract

The activity of a crude extract formulation was evaluated in experimental amoebic liver abscess in golden hamsters and in immunomodulation studies. The formulation comprises the following five plants-Boerhavia diffusa, Tinospora cordifolia, Berberis aristata, Terminalia chebula and Zingiber officinale. The formulation had a maximum cure rate of 73% at a dose of 800 mg/kg/day in hepatic amoebiasis reducing the average degree of infection (ADI) to 1.3 as compared to 4.2 for sham-treated controls. In immunomodulation studies humoral immunity was enhanced as evidenced by the haemagglutination titre. The T-cell counts remained unaffected in the animals treated with the formulation but cell-mediated immune response was stimulated as observed in the leukocyte migration inhibition (LMI) tests.

References

Dec 1, 1992·Medical Hypotheses·K C Srivastava, T Mustafa
May 1, 1994·Journal of Natural Products·C V DenyerD A Young
Aug 1, 1993·Anaesthesia·S PhillipsS E Hutchinson

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Citations

Oct 1, 1975·Experimental and Molecular Pathology·B N TandonP C Gandhi
Aug 22, 2002·International Immunopharmacology·S MehrotraV K Singh
Nov 3, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Premalatha Balachandran, Rajgopal Govindarajan
Dec 20, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R P SinghA R Rao
Sep 20, 2002·The Journal of Toxicological Sciences·Biswadev BishayiMahuya Sengupta
Sep 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Sensen ChiBin Liu
Jan 2, 2008·Phytotherapy Research : PTR·T S PanchabhaiN N Rege
May 29, 2010·Immunopharmacology and Immunotoxicology·Mohammed GhonimeHesham Soliman
Jun 9, 2009·Phytotherapy Research : PTR·Jyoti BhatGautam Banerjee
May 11, 2004·Journal of Radiation Research·Harish Chandra GoelRuchi Dogra

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