Nov 13, 2019

Activity of Aerosolized Levofloxacin against Burkholderia cepacia in a Mouse Model of Chronic Lung Infection

Antimicrobial Agents and Chemotherapy
Mojgan Sabet, David C Griffith

Abstract

Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from patients with cystic fibrosis. Treatment with aerosolized levofloxacin for 4 days produced at least 1 log CFU of bacterial killing against all strains tested, suggesting possible utility in the treatment of lung infections caused by B. cepacia isolates.

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Mentioned in this Paper

Study
Recurrent Lower Respiratory Tract Infection
Infectious Disease of Lung
Cystic Fibrosis
Burkholderia cepacia complex
Burkholderia cepacia
Isolate - Microorganism
Levofloxacin
Bacterial Infections

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