PMID: 11327663May 1, 2001Paper

Activity of amphotericin B in lipid emulsion in the initial treatment of canine leishmaniasis

The Journal of Small Animal Practice
J Lamothe

Abstract

Amphotericin B was given to 19 dogs with leishmaniasis. The drug was diluted in an emulsion prepared by mixing 50 mg of amphotericin B desoxycholate with 40 ml of sterile water and 10 ml of soya bean oil solution. The dogs were infused over nearly one hour with 50 ml/kg of normal saline followed by 10 ml/kg of mannitol 20 per cent. The mixture was then loaded over 30 to 60 minutes using a syringe pump. The emulsion was given twice weekly, at an increasing dosage (from 1 to 2.5 mg/kg bodyweight), for a minimum of eight injections. All 17 dogs receiving a total dosage of more than 10 mg/kg were clinically cured by the end of the treatment, and 14 of these had a negative polymerase chain reaction test on bone marrow.

References

Jul 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·R MolinaJ Alvar
May 20, 1995·The Veterinary Record·L FerrerM Portús
Dec 1, 1995·The Journal of Antimicrobial Chemotherapy·G OlivaA Persechino
Jan 1, 1997·La Revue de médecine interne·P Chavanet
Aug 1, 1997·The Journal of Pediatrics·L di MartinoA D Bryceson
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·S WalkerA E Simor
Jun 17, 1998·Annals of Tropical Medicine and Parasitology·O F OsmanL Oskam
Jul 23, 1998·The Journal of Small Animal Practice·P J GinelJ M Molleda
Mar 3, 1999·The Journal of Antimicrobial Chemotherapy·S MaesakiS Kohno
Apr 21, 1999·The Veterinary Record·X RouraL Ferrer
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S SundarH W Murray
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder

❮ Previous
Next ❯

Citations

Apr 12, 2005·Applied Microbiology and Biotechnology·A LemkeO Kayser
Jun 25, 2002·Veterinary Parasitology·Gad Baneth, Susan E Shaw
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Malika LarabiGillian Barratt
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·J A Sánchez-BruneteJ J Torrado
Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·M SayariF Barati
Jul 21, 2011·Veterinary Medicine International·Michele Podaliri VulpianiNicola Ferri
Jul 17, 2007·International Journal of Antimicrobial Agents·Lara Ordóñez-GutiérrezJosé María Alunda
Aug 17, 2005·Veterinary Dermatology·Chiara Noli, Silvia T Auxilia
Dec 7, 2007·Biomedical Chromatography : BMC·R EspadaJ J Torrado
Nov 10, 2006·Australian Veterinary Journal·C R O'BrienR Malik
Jan 28, 2014·Veterinary Dermatology·Manolis N Saridomichelakis, Alexander F Koutinas
Aug 11, 2001·The Veterinary Record·P VolpeL Iannetti
Aug 31, 2002·The Veterinary Record·J Lamothe, A Poujade
Jan 23, 2021·RSC Medicinal Chemistry·Paula Faral-TelloCarlos Robello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.