PMID: 9660468Jul 11, 1998Paper

Activity of anticancer compounds against Trypanosoma cruzi-infected mice

The American Journal of Tropical Medicine and Hygiene
K E KinnamonV B Waits

Abstract

Chagas' disease, which is caused by Trypanosoma cruzi, remains essentially incurable. Due principally to a lack of profit incentive, the pharmaceutical industry has had limited interest in developing new antichagasic drugs. Thus, a search for agents that exhibit activity against T. cruzi, although medicaments have been developed for the treatment of other diseases, seems justifiable. Responding to evidence that the principal biochemical differences between mammalian cells and African trypanosomes apply equally to T. cruzi, our evaluations were conducted. Previous work showed the effectiveness of anticancer agents against T. rhodesiense. In the present studies, 76 anticancer compounds were assessed for their ability to suppress the trypomastigotes of T. cruzi- infected mice. Five compounds were found to be active. The most effective was cycloheximide, which was more than six times as effective as the standard, nifurtimox.

Citations

Apr 27, 2000·Proceedings of the Society for Experimental Biology and Medicine·K E KinnamonM T Dzimianski
Dec 13, 2012·Future Oncology·Hossein Yousofi Darani, Morteza Yousefi
Dec 23, 2003·Infection and Immunity·Eric DumonteilMaria Jesus Ramirez-Sierra

❮ Previous
Next ❯

Related Concepts

© 2022 Meta ULC. All rights reserved