Activity of cefepime against ceftazidime- and cefotaxime-resistant gram-negative bacteria and its relationship to beta-lactamase levels.

Antimicrobial Agents and Chemotherapy
J Fung-TomcR E Kessler

Abstract

One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91% were resistant to cefotaxime, 84% were resistant to ceftazidime, and 6% were resistant to cefepime. Of the members of the family Enterobacteriaceae, 57% were resistant to ceftriaxone. The six strains resistant to cefepime were all Pseudomonas aeruginosa and were resistant to both cefotaxime and ceftazidime. Cefepime-resistant P. aeruginosa strains had exceptionally high levels of beta-lactamase activity, higher than the levels found in strains resistant to ceftazidime but susceptible to cefepime. The beta-lactamases from the cefepime-resistant strains were type I (Richmond-Sykes), were constitutively produced, and did not have increased affinity or hydrolytic activity for cefepime. Thus, cefepime was active against most gram-negative bacteria which have developed resistance to the broad-spectrum cephalosporins, and resistance to cefepime in P. aeruginosa appears to be associated with higher beta-lactamase levels t...Continue Reading

References

Jan 1, 1985·Pharmacology & Therapeutics·H Nikaido
Aug 1, 1987·European Journal of Clinical Microbiology·F FollathJ Meyer
Sep 1, 1988·Antimicrobial Agents and Chemotherapy·J Fung-TomcR E Kessler
Aug 1, 1987·European Journal of Clinical Microbiology·C C Sanders, W E Sanders
Nov 1, 1986·The Journal of Infectious Diseases·C C Sanders, W E Sanders
Aug 1, 1987·European Journal of Clinical Microbiology·D L DworzackE A Horowitz
May 1, 1986·Antimicrobial Agents and Chemotherapy·D J PhelpsR E Kessler
May 1, 1987·The Journal of Infectious Diseases·J P QuinnJ Foster
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·R E KesslerF Leitner
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Jun 1, 1974·The Biochemical Journal·S G Waley
Jan 1, 1973·Advances in Microbial Physiology·M H Richmond, R B Sykes
Sep 1, 1984·The Journal of Antimicrobial Chemotherapy·R A Benn, R J Kemp

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Citations

Feb 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P DomenicoB A Cunha
Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Martínez-BeltránF Baquero
Feb 11, 2000·Diagnostic Microbiology and Infectious Disease·A Ponce-de-LeónJ Sifuentes-Osornio
Apr 17, 2001·The Pediatric Infectious Disease Journal·A C Arrieta, J S Bradley
Apr 17, 2001·The Pediatric Infectious Disease Journal·X Sáez-Llorens, M O'Ryan
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·S OsterR McCabe
Aug 1, 1993·Antimicrobial Agents and Chemotherapy·J A WashingtonC C Knapp
Feb 1, 1995·Antimicrobial Agents and Chemotherapy·J C Fung-TomcD P Bonner
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·R S MaloneI Teitelbaum
Nov 6, 2007·Expert Opinion on Emerging Drugs·Malcolm G P Page
Jun 18, 2011·The Medical Clinics of North America·Luke F ChenKeith S Kaye
Apr 24, 2007·The Lancet Infectious Diseases·Dafna YahavLeonard Leibovici
Jun 24, 1996·The American Journal of Medicine·J Segreti, S Levin
Jun 24, 1996·The American Journal of Medicine·M Rybak
Jun 24, 1996·The American Journal of Medicine·R SchwartzE Frank
Jun 1, 1997·Journal of Chemotherapy·A AufieroA La Regina
Mar 1, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Gilles Beaucaire
Jul 19, 2019·Clinical Microbiology Reviews·Anne Davin-RegliJean-Marie Pagès
Jul 14, 1998·Antimicrobial Agents and Chemotherapy·P D ListerC C Sanders
May 1, 1996·Antimicrobial Agents and Chemotherapy·J C Fung-TomcD P Bonner

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