Activity of common anticonvulsant drugs on spinal seizure-induced by sudden cooling

Progress in Neuro-psychopharmacology & Biological Psychiatry
J C Piña-Crespo, Nelson L Daló

Abstract

Although some of the clinical signs associated with epilepsy have their origin in supraspinal structures, it is the spinal cord in the end, which is responsible for generating the typical pattern of tonic-clonic contractions associated with a convulsion. Indeed, the spinal cord isolated from influence of the brain is capable of convulsive and paroxysmal activity that exhibits the same stereotyped motor pattern seen in the intact animal. This motor pattern can be reproduced experimentally by cooling the isolated spinal cord of amphibians. The isolated spinal cord-hindleg preparation of toad was used. Convulsive activity was induced by placing the isolated spinal cord into a Ringer's bath kept at 7 degrees C. The characteristic phases of the convulsion and their intensity were assessed by recording tonic-clonic contractions of hindleg muscles. Two main endpoints were used to assess the anticonvulsive activity of the drugs tested: first, their ability to block only the tonic hind-limb extension (THE) and second, their ability to block all tonic-clonic activity. The ED50 values and its 95% confidence interval estimated for abolition of THE for each drugs was (mg/kg): carbamazepine 8.6 (6.8-10.8), phenytoin 13 (7.1-23.6), diazepam 0...Continue Reading

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Citations

Jan 25, 2007·International Journal of Experimental Pathology·Nelson L DalóJuan C Piña-Crespo
Jul 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas Arendt, Torsten Bullmann

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