PMID: 21857075Aug 23, 2011Paper

Activity of essential phospholipids (EPL) from soybean in liver diseases

Pharmacological Reports : PR
K J GundermannMarek Droździk

Abstract

Essential phospholipids (EPL) contain a highly purified extract of polyenylphosphatidylcholine (PPC) molecules from soybean. The main active ingredient is 1,2-dilinoleoylphosphatidylcholine (DLPC), which differentiates it from other phospholipids, lecithins, or extracts from other sources. Although EPLis widely used in liver diseases of various origins, its mode of action and pharmacological and clinical evidence of its efficacy have not yet been concisely reviewed. This paper critically summarizes experimental and clinical results. With regard to in-vitro and animal tests, EPL influenced membrane-dependent cellular functions and showed anti-oxidant, anti-inflammatory, anti-fibrotic, apoptosis-modulating, regenerative, membrane-repairing and -protective, cell-signaling and receptor-influencing, as well as lipid-regulating effects in intoxication models with chemicals or drugs. Clinical studies, primarily from European and Asian countries, have shown improvement in subjective symptoms; clinical, biochemical and imaging findings; and histology in liver indications such as fatty liver of different origin, drug hepatotoxicity, and adjuvant in chronic viral hepatitis and hepatic coma. The available studies characterize EPL as eviden...Continue Reading

References

Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LiC S Lieber
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BendtsenJ H Henriksen
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberM A Leo
Jan 1, 1990·Biorheology·S Chien, L P Sung
May 1, 1986·Clinical Science·C GuarnerF Vilardell
Nov 15, 1973·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A PoulosI G White
Nov 1, 1973·Biochemical and Biophysical Research Communications·J A Sands
Feb 1, 1995·Biochemical Society Transactions·P W PembertonR W Lobley
Sep 1, 1993·Scientific American·H Wigzell
Apr 1, 1997·Alcoholism, Clinical and Experimental Research·C S LieberL M DeCarli
Dec 10, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D ShawV Murray
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K E ShermanZ D Goodman
Jul 24, 1998·Biochemical and Biophysical Research Communications·L M BradyC J Fimmel
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·M K AleynikC S Lieber
Apr 28, 1999·Free Radical Biology & Medicine·S I AleynikC S Lieber
Apr 28, 1999·The Journal of Laboratory and Clinical Medicine·J PoniachikC S Lieber
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Nov 24, 1999·The Journal of Laboratory and Clinical Medicine·C M OnetaC S Lieber
Jan 15, 2000·The Journal of Pediatrics·S E LedermannR S Trompeter
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·S I AleynikC S Lieber
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·L J MiC S Lieber
Jun 16, 2001·Clinical Biochemistry·G G KatzM G Neuman
Aug 23, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M LaccettiA Balzano
Nov 2, 2001·Biochemical and Biophysical Research Communications·M K Aleynik, C S Lieber
Feb 28, 2002·Biochemical and Biophysical Research Communications·Khursheed P Navder, Charles S Lieber
Apr 23, 2002·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S DemirbilekM Bitiren
May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Robert J Cushley, Mark Okon

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Citations

Oct 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yong-Song Guan, Qing He
Sep 18, 2015·Diabetes/metabolism Research and Reviews·Rauf ShahbazovBashoo Naziruddin
Aug 6, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Castro-GómezJ Fontecha
Mar 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junaid KhanShailendra Saraf
Oct 1, 2019·Gastroenterology Research and Practice·Meijuan ChenHongying Pan
May 16, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N V MedvedevaO M Ipatova
Nov 4, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O N VoloshchukG P Kopylchuk
Nov 28, 2020·The British Journal of Nutrition·Purevsuren LosolChristopher Torrens
Oct 26, 2013·Journal of Agricultural and Food Chemistry·Paolo LucciGian Luigi Gianfranceschi
Jan 10, 2012·Lipids in Health and Disease·Daniela KüllenbergUlrich Massing

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