Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models

Future Medicinal Chemistry
Junya de Lacorte SingulaniMaria José Soares Mendes-Giannini

Abstract

Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length.

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Citations

Nov 14, 2019·Plants·Reginaldo Dos Santos PedrosoRegina Helena Pires
Nov 5, 2019·Frontiers in Microbiology·Karen G N OshiroOctávio Luiz Franco
Oct 25, 2020·The European Journal of Neuroscience·Giovanni AnnonaMarina Paolucci

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Methods Mentioned

BETA
transgenic

Software Mentioned

GraphPad Prism

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