PMID: 4235Apr 1, 1976

Activity of gamma-glutamyl transpeptidase in serum of patients receiving anticonvulsant of anticoagulant therapy

Clinical Biochemistry
D Acheampong-Mensah

Abstract

1. Effects of chronic anticoagulant therapy in heart patients and anticonvulsant therapy in epileptics on gamma-glutamyl transpeptidase activity in serum were investigated. 2. The enzyme was elevated in 22% of 18 patients receiving anticoagulants. In these patients prothrombin time was also abnormally high. 3. 84% of 65 epileptics exhibited elevated gamma-glutamyl transpeptidase activity, 67% of which were not associated with elevated alkaline phosphatase or aspartate aminotransferase activities. In these latter cases, involvement of the liver was not apparent. 4. Possible relationships of anticonvulsant mediated enzyme induction or hepatic toxicity to elevated gamma-glutamyl transpeptidase activity in serum in epileptics is discussed.

References

Apr 1, 1972·Archives of Internal Medicine·J PojerT F Williams

Citations

Oct 1, 1986·Digestive Diseases and Sciences·E B KeeffeJ D Gabourel
Jan 1, 1999·Indian Journal of Clinical Biochemistry : IJCB·P L Wolf
Jan 1, 1980·Addictive Behaviors·E Reyes, W R Miller
Aug 31, 2006·Pediatric Neurology·Gal Dubnov-RazPaul Merlob
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·R E Brown, D T Forman

Related Concepts

Alkaline Phosphatase
Indirect Thrombin Inhibitors
Anticonvulsants
SGOT - Glutamate oxaloacetate transaminase
Single Seizure
Gamma-glutamyl transferase
Luminal
Hydantol
Thrombotest

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