PMID: 8954134Nov 22, 1996Paper

Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid

Biochimica Et Biophysica Acta
Y Kabir, T Ide

Abstract

The activity of hepatic fatty acid oxidation enzymes in rats fed linseed and perilla oils rich in alpha-linolenic acid (alpha-18:3) was compared to that in rats fed safflower oil rich in linoleic acid (18:2) and a saturated fat (palm oil). Palm and safflower oils were essentially devoid of alpha-18:3. The palmitoyl-CoA oxidation rates both in mitochondrial and peroxisomal pathways in liver homogenates were significantly higher in rats fed linseed oil than in those fed palm and safflower oils. Among rats fed diets containing palm oil, safflower oil, fat mixtures composed of safflower and perilla oils (2:1, w/w and 1:2, w/w), and perilla oil, mitochondrial and peroxisomal fatty oxidation rates increased with increasing dietary levels of perilla oil. Compared to palm and safflower oils, dietary alpha-18:3 either in the form of linseed or perilla oils profoundly increased the activity of carnitine palmitoyltransferase, acyl-CoA oxidase, 3-ketoacyl-CoA thiolase, and 2,4-dienoyl-CoA reductase. Smaller but significant increases by dietary alpha-18:3 of the activity of acyl-CoA dehydrogenase, enoyl-CoA hydratase, and delta 3, delta 2-enoyl-CoA isomerase were also observed. Unexpectedly, dietary alpha-18:3 greatly reduced the activity o...Continue Reading

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Citations

Feb 25, 2005·Lipids·Manabu T NakamuraTakayuki Y Nara
May 26, 2004·Biochimica Et Biophysica Acta·Takashi IdeMichihiro Sugano
Jan 9, 2004·The Journal of Nutritional Biochemistry·Anne MoriseDominique Hermier
Nov 10, 2005·Public Health Nutrition·Ricardo Uauy, Erik Díaz
Aug 31, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N GuelzimD Hermier
Oct 16, 2015·Journal of Agricultural and Food Chemistry·Toru Hashimoto, Takashi Ide
Oct 27, 1999·Metabolism: Clinical and Experimental·L AshakumaryM Sugano
Oct 8, 2004·The British Journal of Nutrition·M JavadiA C Beynen
May 3, 2008·Biological & Pharmaceutical Bulletin·Tetsuya AdachiGozoh Tsujimoto
Jul 28, 2005·Reproduction, Nutrition, Development·Anne MoriseDominique Hermier
Sep 4, 2020·Biological & Pharmaceutical Bulletin·Takashi Ide, Izumi Origuchi
Feb 24, 2020·Molecular Genetics and Metabolism·Nicola Hale

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