PMID: 3214071Jan 1, 1988Paper

Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections

Annals of the New York Academy of Sciences
J F RyleyR G Wilson

Abstract

ICI 195,739 shows superior potency to other azoles in eliminating vaginal candidosis or dermatophyte infections in animal models of infection by both oral dosing and topical application; effective doses are in the range of 0.5-5.0 mg/kg/day or 0.01-0.30% in a topical formulation. ICI 195,739 is likewise effective in models of systemic fungal infection; 1, 10, 25 mg/kg/day will protect animals given a lethal inoculum of C. albicans, C. neoformans, or A. fumigatus, respectively, as long as dosing is continued, showing activity in this respect superior to that of other azoles tested. ICI 195,739 will suppress infections in mice with T. cruzi and prevent mortality with five daily doses of 1 mg/kg; cure rather than suppression of patent infections has been achieved with 35 daily doses of 10 mg/kg.

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Citations

Apr 1, 1997·Parasitology Today·R Docampo, G A Schmuñis
Jan 1, 1990·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·J F Ryley, N G Ryley
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·T TanioT Okuda
Nov 1, 1993·Antimicrobial Agents and Chemotherapy·H YamadaH Mochizuki
May 1, 1993·Antimicrobial Agents and Chemotherapy·K V ClemonsD A Stevens
Jul 1, 1996·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·K V ClemonsD A Stevens
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·H MiethJ G Meingassner
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·K V Clemons, D A Stevens
Feb 1, 1997·Expert Opinion on Investigational Drugs·J C Fung-Tomc, D P Bonner
Jul 5, 2016·Expert Opinion on Therapeutic Patents·Juan B RodriguezSergio H Szajnman
Jan 1, 1988·Annals of the New York Academy of Sciences·F T BoyleJ M Wardleworth
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Apr 12, 2018·Current Medicinal Chemistry·Elena AguileraMercedes González

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