Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay

Journal of Natural Products
Qin PanZhi-Da Min

Abstract

Three new macrocyclic diterpenes, kansuinins F (1), G (2), and H (3), together with four known jatrophane diterpenes, kansuinins D (4), E (5), and A (6) and 3beta,5alpha,7beta,15beta-tetraacetoxy-9alpha-nicotinoyloxyjatropha-6(17)-11E-dien-14-one, were isolated from the roots of Euphorbia kansui. Compounds 1 and 2 were assigned as 6(17)-en-11,12-epoxy-14-one-type jatrophane diterpenes, and compound 3 as a 6(17)-en-11,14-epoxy-12-one jatrophane diterpene. The structures of compounds 1-3 and the relative configurations of compounds 4 and 5 were determined by spectral data analysis. Kansuinin E (5) exhibited a specific survival effect on fibroblasts that expressed TrkA, a high-affinity receptor for nerve growth factor.

References

Jul 7, 1999·Phytochemistry·J HohmannG Jerkovich

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Citations

Oct 22, 2009·Journal of Natural Medicines·Xiaoyun ShuXiangchun Shen
Oct 12, 2012·Archives of Pharmacal Research·Piseth KhievSei-Ryang Oh
Jun 15, 2011·Natural Product Research·Xiao-Qi ZhangWen-Cai Ye
Apr 16, 2016·The American Journal of Chinese Medicine·Juan ShenJin-Ao Duan
Nov 19, 2011·Phytotherapy Research : PTR·Hong-Ying WangLing-Yi Kong
Dec 20, 2013·Angewandte Chemie·Jing XuEmmanuel A Theodorakis
Dec 13, 2019·Chemical Communications : Chem Comm·Linlin ShiZhen Yang
Apr 16, 2020·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Maryam FattahianIkhlas A Khan
Aug 19, 2015·Journal of the Science of Food and Agriculture·Sehyun OhJae Wha Kim
May 14, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hong MaYaozhou Zhang
Sep 27, 2008·Chemical Reviews·Qing-Wen ShiHiromasa Kiyota
Mar 7, 2008·Journal of Natural Products·Zhi-Qiang LuDe-An Guo

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