Activity of mecillinam against Escherichia coli resistant to third-generation cephalosporins

The Journal of Antimicrobial Chemotherapy
Mandy WoottonRobin A Howe

Abstract

To assess the activity of mecillinam against two groups of Escherichia coli: (i) a selection of international isolates with mechanisms of resistance caused by the presence of defined beta-lactamases; and (ii) isolates resistant to third-generation cephalosporins referred from across Wales. Antibiotic susceptibility testing with mecillinam, meropenem, amoxicillin, co-amoxiclav, cefotaxime, piperacillin/tazobactam, ciprofloxacin, nitrofurantoin, trimethoprim and gentamicin was performed using the BSAC agar dilution method against 30 international strains of E. coli with known beta-lactamase presence. Antibiotic susceptibility testing with mecillinam using the same method was performed against 325 regional isolates of E. coli resistant to third-generation cephalosporins. The susceptibility results showed that the only antibiotics to which the 30 international isolates were consistently susceptible were mecillinam (100%) and meropenem (100%), irrespective of the presence of beta-lactamases. Of the local isolates, 93.5% (304/325) were susceptible to mecillinam, having MICs < 8 mg/L. Our results show that mecillinam has excellent in vitro activity against a range of E. coli exhibiting beta-lactamase activity, some with the production...Continue Reading

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Citations

Sep 17, 2013·Nature Communications·Lesley A OgilvieBrian V Jones
Feb 26, 2010·The Journal of Antimicrobial Chemotherapy·R J ChislettD P J Turner
Jun 14, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Alasdair MacGowan, Maha Albur
Oct 5, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N T MuttersA Mischnik
Jun 2, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C G Giske
May 14, 2016·Expert Review of Clinical Pharmacology·Noha El Sakka, Ian M Gould
Nov 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H SyreI H Löhr
May 23, 2020·The Journal of Antimicrobial Chemotherapy·Adam G StewartDavid L Paterson

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