Activity of medicinal plants from Ghana against the parasitic gut protist Blastocystis

Journal of Ethnopharmacology
Charlotte Bremer ChristensenA K Jäger

Abstract

The plants tested in this study were examples of plants historically used to treat or alleviate several types of stomach disorders manifested by e.g. stomachache, diarrhoea or dysentery. These plants have been consumed typically as a decoction, sometimes mixed with other flavourings. The aim of this study was to evaluate the anti-Blastocystis activity of 24 plant parts from 21 medicinal plants from Ghana. The medicinal plants were collected in the Greater Accra region of Ghana. Every plant part was tested in three different extracts; an ethanolic, a warm, and a cold water extract, at a final concentration of 1 mg/mL for the initial screening, and in a range from 0.0156 to 1mg/mL for determination of inhibitory concentrations. The obligate anaerobic parasitic gut protist Blastocystis (subtype 4) was used as a 48 h old subcultivated isolate in the final concentration of 10(6) cells/mL. Plant extracts inoculated with Blastocystis were incubated at 37 °C for 24 h and 48 h. Both MIC minimum inhibitory concentration (MIC90) assays and minimal lethal concentration (MLC) assays were performed after 24 h and 48 h. The half maximal inhibitory concentration (IC50) was derived after 24 h and 48 h. Antimicrobial activity was tested against ...Continue Reading

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Citations

Jan 19, 2016·Parasitology International·Özgür KurtMehmet Tanyüksel
Mar 23, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LepczyńskaJ Korycińska
May 7, 2019·International Journal of Environmental Research and Public Health·Amira B MokhtarPanagiotis Karanis
Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank

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