Activity of murein hydrolases in synchronized cultures of Escherichia coli.

Journal of Bacteriology
R Hakenbeck, W Messer

Abstract

Murein hydrolase activities were analyzed in synchronized cultures of Escherichia coli B/r. Cell wall-bound murein hydrolase activities, including the penicillin-sensitive endopeptidase, increased discontinuously during the cell cycle and showed maximum activity at a cell age of 30 to 35 min (generation time, 43 min). Maximum activity was observed at the same time that the rate of cell wall synthesis reached its maximum. These oscillations depended on the termination of replication: no increase in hydrolase activity was found if deoxyribonucleic acid synthesis was inhibited at an early time in the life cycle. In contrast, the activity of another murein hydrolase that was not tightly bound to the membrane (transglycosylase) increased exponentially with time, even when deoxyribonucleic acid synthesis was inhibited.

References

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Citations

Apr 1, 1982·Journal of Bacteriology·J S Poindexter, J G Hagenzieker
Jan 1, 1984·Pharmacology & Therapeutics·J B Ward
Mar 1, 1978·Journal of Bacteriology·C Zuchowski, O Pierucci
Jan 1, 1981·Journal of Bacteriology·C E Carty, L O Ingram
Jul 1, 1983·Infection and Immunity·T A Kral, L Daneo-Moore
Aug 1, 1979·Journal of Bacteriology·D M Ferber, R R Brubaker
Oct 1, 1980·Biochimica Et Biophysica Acta·K Bieńkowska-Szewczyk, A Taylor
May 1, 1978·Journal of Bacteriology·D MirelmanE Z Ron
Aug 1, 1978·Antimicrobial Agents and Chemotherapy·K IidaM Koike
Jun 20, 1978·Journal of Theoretical Biology·R A Krasnow
Jan 1, 1985·Biochimie·D Joseleau-Petit

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